FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105066596> ?p ?o ?g. }

• W2105066596 endingPage "856" @default.
• W2105066596 startingPage "846" @default.
• W2105066596 abstract "A(1) adenosine receptor (AR) antagonists are effective diuretic agents that may be useful for treating fluid retention disorders including congestive heart failure. However, antagonism of A(1)ARs is potentially a concern when using these agents in patients with ischemic heart disease. To address this concern, the present study was designed to compare the actions of the A(1)AR antagonists CPX (1,3-dipropyl-8-cyclopentylxanthine), BG 9719 (1,3-dipropyl-8-[2-(5,6-epoxynorbornyl)]xanthine), and BG 9928 (1,3-dipropyl-8-[1-(4-propionate)-bicyclo-[2,2,2]octyl]xanthine) on acute myocardial ischemia/reperfusion injury and ischemic preconditioning (IPC) in an in vivo dog model of infarction. Barbital-anesthetized dogs were subjected to 60 min of left anterior descending coronary artery occlusion followed by 3 h of reperfusion, after which infarct size was assessed by staining with triphenyltetrazolium chloride. IPC was elicited by four 5-min occlusion/5-min reperfusion cycles produced 10 min before the 60-min occlusion. Multiple-cycle IPC produced a robust reduction ( approximately 65%) in infarct size; this effect of IPC on infarct size was not abrogated in dogs pretreated with any of the three AR antagonists. Surprisingly, in the absence of IPC, pretreatment with CPX or BG 9928 before occlusion or immediately before reperfusion resulted in significant reductions ( approximately 40-50%) in myocardial infarct size. However, treatment with an equivalent dose of BG 9719 had no similar effect. We conclude that the A(1)AR antagonists BG 9719, BG 9928, and CPX do not exacerbate cardiac injury and do not interfere with IPC induced by multiple ischemia/reperfusion cycles. We discuss the possibility that the cardioprotective actions of CPX and BG 9928 may be related to antagonism of A(2B)ARs." @default.
• W2105066596 created "2016-06-24" @default.
• W2105066596 creator A5026179512 @default.
• W2105066596 creator A5030692703 @default.
• W2105066596 creator A5031860646 @default.
• W2105066596 creator A5035915140 @default.
• W2105066596 creator A5047716997 @default.
• W2105066596 creator A5047732235 @default.
• W2105066596 creator A5048240825 @default.
• W2105066596 creator A5057869524 @default.
• W2105066596 creator A5060190034 @default.
• W2105066596 creator A5066211429 @default.
• W2105066596 creator A5066788141 @default.
• W2105066596 creator A5067930209 @default.
• W2105066596 date "2003-11-21" @default.
• W2105066596 modified "2023-10-15" @default.
• W2105066596 title "Comparison of Three Different A₁Adenosine Receptor Antagonists on Infarct Size and Multiple Cycle Ischemic Preconditioning in Anesthetized Dogs" @default.
• W2105066596 cites W125482507 @default.
• W2105066596 cites W1484320289 @default.
• W2105066596 cites W1970592808 @default.
• W2105066596 cites W1986905765 @default.
• W2105066596 cites W1996409370 @default.
• W2105066596 cites W2006397919 @default.
• W2105066596 cites W2006489146 @default.
• W2105066596 cites W2008952071 @default.
• W2105066596 cites W2014076464 @default.
• W2105066596 cites W2017977690 @default.
• W2105066596 cites W2022468880 @default.
• W2105066596 cites W2026493105 @default.
• W2105066596 cites W2034082628 @default.
• W2105066596 cites W2035807568 @default.
• W2105066596 cites W2047808472 @default.
• W2105066596 cites W2050447662 @default.
• W2105066596 cites W2061469017 @default.
• W2105066596 cites W2061890387 @default.
• W2105066596 cites W2087070363 @default.
• W2105066596 cites W2106004128 @default.
• W2105066596 cites W2110204147 @default.
• W2105066596 cites W2116418941 @default.
• W2105066596 cites W2140292987 @default.
• W2105066596 cites W2158983804 @default.
• W2105066596 cites W2159193479 @default.
• W2105066596 cites W2159893444 @default.
• W2105066596 cites W2269172808 @default.
• W2105066596 cites W4239896380 @default.
• W2105066596 doi "https://doi.org/10.1124/jpet.103.057943" @default.
• W2105066596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2430467" @default.
• W2105066596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14634049" @default.
• W2105066596 hasPublicationYear "2003" @default.
• W2105066596 type Work @default.
• W2105066596 sameAs 2105066596 @default.
• W2105066596 citedByCount "38" @default.
• W2105066596 countsByYear W21050665962012 @default.
• W2105066596 countsByYear W21050665962014 @default.
• W2105066596 countsByYear W21050665962015 @default.
• W2105066596 countsByYear W21050665962016 @default.
• W2105066596 countsByYear W21050665962017 @default.
• W2105066596 countsByYear W21050665962019 @default.
• W2105066596 countsByYear W21050665962022 @default.
• W2105066596 crossrefType "journal-article" @default.
• W2105066596 hasAuthorship W2105066596A5026179512 @default.
• W2105066596 hasAuthorship W2105066596A5030692703 @default.
• W2105066596 hasAuthorship W2105066596A5031860646 @default.
• W2105066596 hasAuthorship W2105066596A5035915140 @default.
• W2105066596 hasAuthorship W2105066596A5047716997 @default.
• W2105066596 hasAuthorship W2105066596A5047732235 @default.
• W2105066596 hasAuthorship W2105066596A5048240825 @default.
• W2105066596 hasAuthorship W2105066596A5057869524 @default.
• W2105066596 hasAuthorship W2105066596A5060190034 @default.
• W2105066596 hasAuthorship W2105066596A5066211429 @default.
• W2105066596 hasAuthorship W2105066596A5066788141 @default.
• W2105066596 hasAuthorship W2105066596A5067930209 @default.
• W2105066596 hasConcept C126322002 @default.
• W2105066596 hasConcept C164705383 @default.
• W2105066596 hasConcept C181199279 @default.
• W2105066596 hasConcept C185592680 @default.
• W2105066596 hasConcept C2776268601 @default.
• W2105066596 hasConcept C2776991684 @default.
• W2105066596 hasConcept C2777798775 @default.
• W2105066596 hasConcept C2778198053 @default.
• W2105066596 hasConcept C2779311647 @default.
• W2105066596 hasConcept C2779470414 @default.
• W2105066596 hasConcept C2780393670 @default.
• W2105066596 hasConcept C42219234 @default.
• W2105066596 hasConcept C500558357 @default.
• W2105066596 hasConcept C541997718 @default.
• W2105066596 hasConcept C55493867 @default.
• W2105066596 hasConcept C71924100 @default.
• W2105066596 hasConcept C98274493 @default.
• W2105066596 hasConceptScore W2105066596C126322002 @default.
• W2105066596 hasConceptScore W2105066596C164705383 @default.
• W2105066596 hasConceptScore W2105066596C181199279 @default.
• W2105066596 hasConceptScore W2105066596C185592680 @default.
• W2105066596 hasConceptScore W2105066596C2776268601 @default.
• W2105066596 hasConceptScore W2105066596C2776991684 @default.
• W2105066596 hasConceptScore W2105066596C2777798775 @default.
• W2105066596 hasConceptScore W2105066596C2778198053 @default.
• W2105066596 hasConceptScore W2105066596C2779311647 @default.

• next