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• W2105075224 abstract "No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Feb 2002CARCINOMA IN SITU AND TUMOR MULTIFOCALITY PREDICT THE RISK OF PROSTATIC URETHRAL INVOLVEMENT AT RADICAL CYSTECTOMY IN MEN WITH TRANSITIONAL CELL CARCINOMA OF THE BLADDER RANDY G. NIXON, SAM S. CHANG, BONNIE J. LAFLEUR, JOSEPH A. SMITH, and MICHAEL S. COOKSON RANDY G. NIXONRANDY G. NIXON More articles by this author , SAM S. CHANGSAM S. CHANG More articles by this author , BONNIE J. LAFLEURBONNIE J. LAFLEUR More articles by this author , JOSEPH A. SMITHJOSEPH A. SMITH More articles by this author , and MICHAEL S. COOKSONMICHAEL S. COOKSON Requests for reprints: Department of Urologic Surgery, Vanderbilt University Medical Center, A-1302 Medical Center North, Nashville, Tennessee 37232-2765. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)69073-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Determining which patients are at risk for prostatic urethral involvement of urothelial carcinoma may alter assessment of the prostatic urethra before radical cystectomy and ultimately influence the choice of urinary diversion. We determined risk factors predictive of prostatic urethral involvement using preoperative bladder tumor characteristics in male patients who underwent radical cystoprostatectomy due to urothelial carcinoma of the bladder. Materials and Methods: We reviewed 192 consecutive radical cystectomy specimens from men with transitional cell carcinoma from June 1995 to June 2000. The prostatic urethra in each specimen was analyzed and urethral involvement was characterized as carcinoma in situ, intraductal invasion or prostatic stromal invasion. We then examined which clinical bladder tumor characteristics correlated with the incidence and extent of prostatic urethral involvement by performing multiple variable analysis. Results: Prostatic urethral involvement was evident in 30 of the 192 patients (15.6%). Of the 80 patients with carcinoma in situ in the bladder 25 (31.3%) had concomitant prostatic urethral involvement with carcinoma, whereas only 5 (4.5%) of the 112 with no evidence of carcinoma in situ had prostatic urethral involvement. Likewise 25 of the 72 patients (34.7%) with multifocal tumors had concomitant prostatic urethral involvement with carcinoma, whereas only 5 (4.2%) of the 120 with no evidence of multifocality had prostatic urethral involvement. In the multiple variable logistic regression model the odds of prostatic urethral involvement were 12 and 15-fold greater when carcinoma in situ and tumor multifocality were present, respectively. Conclusions: Carcinoma in situ and/or tumor multifocality are valuable prognostic indicators of prostatic urethral involvement. However, in their absence prostatic urethral involvement was rare. Ultimately the extent of prostatic urethral involvement may influence decisions, such as the choice of urinary diversion and need for urethrectomy, in men undergoing radical cystectomy. References 1 : Carcinoma originating in ducts surrounding the prostatic urethra. Am J Clin Pathol1963; 40: 183. Google Scholar 2 : Transitional cell carcinoma of the prostate. J Urol1969; 101: 206. Link, Google Scholar 3 : Transitional cell carcinoma of the prostate. Cancer1969; 24: 543. Google Scholar 4 : Urethral remnant tumors following simultaneous partial urethrectomy and cystectomy for bladder carcinoma. 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J Urol2001; 165: 1117. Link, Google Scholar 18 AJCC Cancer Staging Handbook, 5th ed. American Joint Committee on Cancer. Philadelphia: Lippincott-Raven1998. Google Scholar 19 : Nerve and seminal sparing radical cystectomy with orthotopic urinary diversion for select patients with superficial bladder cancer: an innovative surgical approach. J Urol2001; 165: 51. Link, Google Scholar 20 : Orthotopic urinary diversion with preservation of erectile and ejaculatory function in men requiring radical cystectomy for nonurothelial malignancy: a new technique. J Urol1999; 161: 1761. Link, Google Scholar From the Department of Urologic Surgery and Division of Biostatistics, Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byvon Rundstedt F, Lerner S, Godoy G, Amiel G, Wheeler T, Truong L and Shen S (2018) Usefulness of Transurethral Biopsy for Staging the Prostatic Urethra before Radical CystectomyJournal of Urology, VOL. 193, NO. 1, (58-63), Online publication date: 1-Jan-2015.Lotan Y (2018) Commentary on Prostate and Urothelial Carcinoma in Cystoprostatectomy SpecimensJournal of Urology, VOL. 179, NO. 5S, (S33-S34), Online publication date: 1-May-2008.Hautmann R, Gschwend J, de Petriconi R, Kron M and Volkmer B (2018) Cystectomy for Transitional Cell Carcinoma of the Bladder: Results of a Surgery Only Series in the Neobladder EraJournal of Urology, VOL. 176, NO. 2, (486-492), Online publication date: 1-Aug-2006. Volume 167Issue 2 Part 1February 2002Page: 502-505 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordscarcinoma, transitional cellcarcinoma in situurotheliumurethracystectomyMetricsAuthor Information RANDY G. NIXON More articles by this author SAM S. CHANG More articles by this author BONNIE J. LAFLEUR More articles by this author JOSEPH A. SMITH More articles by this author MICHAEL S. COOKSON Requests for reprints: Department of Urologic Surgery, Vanderbilt University Medical Center, A-1302 Medical Center North, Nashville, Tennessee 37232-2765. More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2105075224 title "CARCINOMA IN SITU AND TUMOR MULTIFOCALITY PREDICT THE RISK OF PROSTATIC URETHRAL INVOLVEMENT AT RADICAL CYSTECTOMY IN MEN WITH TRANSITIONAL CELL CARCINOMA OF THE BLADDER" @default.
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