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- W2105089699 abstract "The ets-family transcription factor PU.1 is required for the proper development of both myeloid and lymphoid progenitors. We used PU.1-deficient animals to examine the role of PU.1 during dendritic cell development. PU.1−/−animals produce lymphoid-derived dendritic cells (DC): low-density class II major histocompatibility complex [MHC-II+] CD11c+ CD8+DEC-205+. But they lack myeloid-derived DC: low-density MHC-II+ CD11c+ CD8−DEC-205−. PU.1−/− embryos also lack progenitors capable of differentiating into myeloid DC in response to granulocyte-macrophage colony-stimulating factor plus interleukin-4. The appearance of lymphoid DC in developing PU.1−/−thymus was initially delayed, but this population recovered to wild type (WT) levels upon organ culture of isolated thymic lobes. PU.1−/−lymphoid DC were functionally equivalent to WT DC for stimulating T-cell proliferation in mixed lymphocyte reactions. These results demonstrate that PU.1 is required for the development of myeloid DC but not lymphoid DC." @default.
- W2105089699 created "2016-06-24" @default.
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- W2105089699 date "2000-02-01" @default.
- W2105089699 modified "2023-10-02" @default.
- W2105089699 title "PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells" @default.
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- W2105089699 doi "https://doi.org/10.1182/blood.v95.3.879.003k13_879_885" @default.
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