FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105102381> ?p ?o ?g. }

• W2105102381 endingPage "111" @default.
• W2105102381 startingPage "100" @default.
• W2105102381 abstract "The epsilon4 allele of the apolipoprotein E (APOE) gene is associated with increased cholesterol levels and heart disease. Population allele frequencies of APOE have previously been shown to vary, with epsilon4 frequencies generally increasing with latitude. We hypothesize that this trend resulted from natural selection protecting against low-cholesterol levels. In high-latitude cold environments and low-latitude hot environments, metabolic rate is elevated, which could require higher cholesterol levels. To explore this hypothesis, we compiled APOE allele frequencies, latitude, temperature, and elevation from populations around the world. epsilon4 allele frequencies show a curvilinear relationship with absolute latitude, with lowest frequencies found in the mid-latitudes where temperatures generally require less expenditure on cooling/thermogenesis. Controlling for population structure in a subset of populations did not appreciably change this pattern of association, consistent with selection pressures that vary by latitude shaping epsilon4 allele frequencies. Temperature records also predict APOE frequency in a curvilinear fashion, with lowest epsilon4 frequencies at moderate temperatures. The model fit between historical temperatures and epsilon4 is less than between latitude and epsilon4, but strengthened after correcting for estimated temperature differences during the Paleolithic. Contrary to our hypothesis, we find that elevation did not improve predictive power, and an integrated measure of the cholesterol effect of multiple APOE alleles was less related to latitude than was epsilon4 alone. Our results lend mixed support for a link between past temperature and human APOE allele distribution and point to the need to develop better models of past climate in future analyses." @default.
• W2105102381 created "2016-06-24" @default.
• W2105102381 creator A5017820742 @default.
• W2105102381 creator A5025762875 @default.
• W2105102381 creator A5087278865 @default.
• W2105102381 date "2010-08-16" @default.
• W2105102381 modified "2023-10-18" @default.
• W2105102381 title "Worldwide allele frequencies of the human apolipoprotein E gene: Climate, local adaptations, and evolutionary history" @default.
• W2105102381 cites W1551429508 @default.
• W2105102381 cites W1631424226 @default.
• W2105102381 cites W1837896746 @default.
• W2105102381 cites W1860877899 @default.
• W2105102381 cites W1936641375 @default.
• W2105102381 cites W1966415237 @default.
• W2105102381 cites W1966425855 @default.
• W2105102381 cites W1969405522 @default.
• W2105102381 cites W1969907992 @default.
• W2105102381 cites W1977286650 @default.
• W2105102381 cites W1977753891 @default.
• W2105102381 cites W1980113310 @default.
• W2105102381 cites W1981856399 @default.
• W2105102381 cites W1982495692 @default.
• W2105102381 cites W1989375145 @default.
• W2105102381 cites W1993729162 @default.
• W2105102381 cites W1994067516 @default.
• W2105102381 cites W1998051879 @default.
• W2105102381 cites W2003742510 @default.
• W2105102381 cites W2004139828 @default.
• W2105102381 cites W2005246739 @default.
• W2105102381 cites W2006437426 @default.
• W2105102381 cites W2007421495 @default.
• W2105102381 cites W2007960303 @default.
• W2105102381 cites W2012297894 @default.
• W2105102381 cites W2018160200 @default.
• W2105102381 cites W2022037814 @default.
• W2105102381 cites W2023474682 @default.
• W2105102381 cites W2029187823 @default.
• W2105102381 cites W2029710795 @default.
• W2105102381 cites W2041948988 @default.
• W2105102381 cites W2047222949 @default.
• W2105102381 cites W2048511011 @default.
• W2105102381 cites W2052466246 @default.
• W2105102381 cites W2056978047 @default.
• W2105102381 cites W2058034919 @default.
• W2105102381 cites W2059053558 @default.
• W2105102381 cites W2059762595 @default.
• W2105102381 cites W2061530946 @default.
• W2105102381 cites W2063607791 @default.
• W2105102381 cites W2065859331 @default.
• W2105102381 cites W2066383852 @default.
• W2105102381 cites W2071115881 @default.
• W2105102381 cites W2072348842 @default.
• W2105102381 cites W2072430086 @default.
• W2105102381 cites W2075113298 @default.
• W2105102381 cites W2075913797 @default.
• W2105102381 cites W2076188504 @default.
• W2105102381 cites W2076553390 @default.
• W2105102381 cites W2078074521 @default.
• W2105102381 cites W2078202376 @default.
• W2105102381 cites W2086705478 @default.
• W2105102381 cites W2086754503 @default.
• W2105102381 cites W2089189677 @default.
• W2105102381 cites W2095859595 @default.
• W2105102381 cites W2096042203 @default.
• W2105102381 cites W2097576041 @default.
• W2105102381 cites W2100198693 @default.
• W2105102381 cites W2105112406 @default.
• W2105102381 cites W2105940408 @default.
• W2105102381 cites W2106611664 @default.
• W2105102381 cites W2108027291 @default.
• W2105102381 cites W2108169091 @default.
• W2105102381 cites W2113281787 @default.
• W2105102381 cites W2114879746 @default.
• W2105102381 cites W2115775861 @default.
• W2105102381 cites W2116937342 @default.
• W2105102381 cites W2118762556 @default.
• W2105102381 cites W2119437653 @default.
• W2105102381 cites W2121101037 @default.
• W2105102381 cites W2121402883 @default.
• W2105102381 cites W2125797839 @default.
• W2105102381 cites W2126700754 @default.
• W2105102381 cites W2128475408 @default.
• W2105102381 cites W2128519424 @default.
• W2105102381 cites W2129357356 @default.
• W2105102381 cites W2143856819 @default.
• W2105102381 cites W2147155212 @default.
• W2105102381 cites W2151602225 @default.
• W2105102381 cites W2156418280 @default.
• W2105102381 cites W2157871575 @default.
• W2105102381 cites W2161633633 @default.
• W2105102381 cites W2162372514 @default.
• W2105102381 cites W2165705696 @default.
• W2105102381 cites W2166512828 @default.
• W2105102381 cites W2167020344 @default.
• W2105102381 cites W2169484904 @default.
• W2105102381 cites W2179153287 @default.
• W2105102381 cites W2318005377 @default.
• W2105102381 cites W2331724060 @default.

• next