FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105113340> ?p ?o ?g. }

• W2105113340 endingPage "8" @default.
• W2105113340 startingPage "1884" @default.
• W2105113340 abstract "We generated transgenic mice for STAT-4, a regulatory protein specifically associated with IL-12 signaling, under the control of a CMV promoter. These mice expressed strikingly increased nuclear STAT-4 levels in lamina propria CD4+ T lymphocytes upon systemic administration of dinitrophenyl-keyhole limpet hemocyanin and developed chronic transmural colitis characterized by infiltrates of mainly CD4+ T lymphocytes. The latter cells produced predominantly TNF and IFN-gamma but not IL-4 upon activation with alphaCD3/CD28 or autologous bacterial Ags, consistent with a Th1-type cell response. Furthermore, chronic colitis in STAT-4 transgenic mice could be adoptively transferred to SCID mice by colonic and splenic CD4+ T cells that were activated with Ags from autologous bacterial flora. These data establish a critical molecular signaling pathway involving STAT-4 for the pathogenesis of chronic intestinal inflammation, and targeting of this pathway may be relevant for the treatment of colitis in humans." @default.
• W2105113340 created "2016-06-24" @default.
• W2105113340 creator A5003042131 @default.
• W2105113340 creator A5009529288 @default.
• W2105113340 creator A5032480207 @default.
• W2105113340 creator A5056873911 @default.
• W2105113340 creator A5066747793 @default.
• W2105113340 creator A5067911784 @default.
• W2105113340 creator A5077586843 @default.
• W2105113340 creator A5083168604 @default.
• W2105113340 date "1999-02-15" @default.
• W2105113340 modified "2023-10-17" @default.
• W2105113340 title "Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF- plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens." @default.
• W2105113340 cites W1991723267 @default.
• W2105113340 cites W1997638368 @default.
• W2105113340 cites W2012083687 @default.
• W2105113340 cites W2012628280 @default.
• W2105113340 cites W2063053561 @default.
• W2105113340 cites W2070242833 @default.
• W2105113340 cites W2093531092 @default.
• W2105113340 cites W2106784406 @default.
• W2105113340 cites W2113855055 @default.
• W2105113340 cites W2118300904 @default.
• W2105113340 cites W2141679700 @default.
• W2105113340 cites W2155898643 @default.
• W2105113340 cites W2159549010 @default.
• W2105113340 cites W2165588484 @default.
• W2105113340 cites W2169436688 @default.
• W2105113340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9973454" @default.
• W2105113340 hasPublicationYear "1999" @default.
• W2105113340 type Work @default.
• W2105113340 sameAs 2105113340 @default.
• W2105113340 citedByCount "61" @default.
• W2105113340 countsByYear W21051133402013 @default.
• W2105113340 countsByYear W21051133402014 @default.
• W2105113340 countsByYear W21051133402015 @default.
• W2105113340 countsByYear W21051133402016 @default.
• W2105113340 countsByYear W21051133402017 @default.
• W2105113340 countsByYear W21051133402018 @default.
• W2105113340 countsByYear W21051133402020 @default.
• W2105113340 countsByYear W21051133402021 @default.
• W2105113340 crossrefType "journal-article" @default.
• W2105113340 hasAuthorship W2105113340A5003042131 @default.
• W2105113340 hasAuthorship W2105113340A5009529288 @default.
• W2105113340 hasAuthorship W2105113340A5032480207 @default.
• W2105113340 hasAuthorship W2105113340A5056873911 @default.
• W2105113340 hasAuthorship W2105113340A5066747793 @default.
• W2105113340 hasAuthorship W2105113340A5067911784 @default.
• W2105113340 hasAuthorship W2105113340A5077586843 @default.
• W2105113340 hasAuthorship W2105113340A5083168604 @default.
• W2105113340 hasConcept C142724271 @default.
• W2105113340 hasConcept C17991360 @default.
• W2105113340 hasConcept C203014093 @default.
• W2105113340 hasConcept C2775862500 @default.
• W2105113340 hasConcept C2776090121 @default.
• W2105113340 hasConcept C2776727803 @default.
• W2105113340 hasConcept C2776914184 @default.
• W2105113340 hasConcept C2777310793 @default.
• W2105113340 hasConcept C2778260677 @default.
• W2105113340 hasConcept C2779134260 @default.
• W2105113340 hasConcept C529295009 @default.
• W2105113340 hasConcept C54355233 @default.
• W2105113340 hasConcept C71924100 @default.
• W2105113340 hasConcept C86803240 @default.
• W2105113340 hasConcept C8891405 @default.
• W2105113340 hasConcept C90375314 @default.
• W2105113340 hasConceptScore W2105113340C142724271 @default.
• W2105113340 hasConceptScore W2105113340C17991360 @default.
• W2105113340 hasConceptScore W2105113340C203014093 @default.
• W2105113340 hasConceptScore W2105113340C2775862500 @default.
• W2105113340 hasConceptScore W2105113340C2776090121 @default.
• W2105113340 hasConceptScore W2105113340C2776727803 @default.
• W2105113340 hasConceptScore W2105113340C2776914184 @default.
• W2105113340 hasConceptScore W2105113340C2777310793 @default.
• W2105113340 hasConceptScore W2105113340C2778260677 @default.
• W2105113340 hasConceptScore W2105113340C2779134260 @default.
• W2105113340 hasConceptScore W2105113340C529295009 @default.
• W2105113340 hasConceptScore W2105113340C54355233 @default.
• W2105113340 hasConceptScore W2105113340C71924100 @default.
• W2105113340 hasConceptScore W2105113340C86803240 @default.
• W2105113340 hasConceptScore W2105113340C8891405 @default.
• W2105113340 hasConceptScore W2105113340C90375314 @default.
• W2105113340 hasIssue "4" @default.
• W2105113340 hasLocation W21051133401 @default.
• W2105113340 hasOpenAccess W2105113340 @default.
• W2105113340 hasPrimaryLocation W21051133401 @default.
• W2105113340 hasRelatedWork W2008854574 @default.
• W2105113340 hasRelatedWork W2015589285 @default.
• W2105113340 hasRelatedWork W2035187012 @default.
• W2105113340 hasRelatedWork W2091256633 @default.
• W2105113340 hasRelatedWork W2154413540 @default.
• W2105113340 hasRelatedWork W2258385876 @default.
• W2105113340 hasRelatedWork W2410358231 @default.
• W2105113340 hasRelatedWork W2418960407 @default.
• W2105113340 hasRelatedWork W3160375196 @default.
• W2105113340 hasRelatedWork W4200218105 @default.
• W2105113340 hasVolume "162" @default.
• W2105113340 isParatext "false" @default.

• next