FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105118448> ?p ?o ?g. }

• W2105118448 endingPage "2105" @default.
• W2105118448 startingPage "2105" @default.
• W2105118448 abstract "ContextBoth bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor α (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results.ObjectiveTo generate large-scale evidence on whether 3 common ESR1 polymorphisms (intron 1 polymorphisms XbaI [dbSNP: rs9340799] and PvuII [dbSNP: rs2234693] and promoter TA repeats microsatellite) and haplotypes thereof are associated with BMD and fractures.Design and SettingMeta-analysis of individual-level data involving standardized genotyping of 18 917 individuals in 8 European centers.Main Outcome MeasuresBMD of femoral neck and lumbar spine; all fractures and vertebral fractures by genotype.ResultsNo between-center heterogeneity was observed for any outcome in any genetic contrast. None of the 3 polymorphisms or haplotypes had any statistically significant effect on BMD in adjusted or unadjusted analyses, and estimated differences between genetic contrasts were 0.01 g/cm2 or less. Conversely, we found significant reductions in fracture risk. In women homozygous for the absence of an XbaI recognition site, the adjusted odds of all fractures were reduced by 19% (odds ratio, 0.81 [95% CI, 0.71-0.93]; P = .002) and vertebral fractures by 35% (odds ratio, 0.65 [95% CI, 0.49-0.87]; P = .003). Effects on fractures were independent of BMD and unaltered in adjusted analyses. No significant effects on fracture risk were seen for PvuII and TA repeats.ConclusionsESR1 is a susceptibility gene for fractures, and XbaI determines fracture risk by mechanisms independent of BMD. Our study demonstrates the value of adequately powered studies with standardized genotyping and clinical outcomes in defining effects of common genetic variants on complex diseases." @default.
• W2105118448 created "2016-06-24" @default.
• W2105118448 creator A5011914418 @default.
• W2105118448 creator A5016379322 @default.
• W2105118448 creator A5019607729 @default.
• W2105118448 creator A5031530236 @default.
• W2105118448 creator A5033638665 @default.
• W2105118448 creator A5034668013 @default.
• W2105118448 creator A5036667571 @default.
• W2105118448 creator A5037877043 @default.
• W2105118448 creator A5038891840 @default.
• W2105118448 creator A5043291392 @default.
• W2105118448 creator A5043643384 @default.
• W2105118448 creator A5052229575 @default.
• W2105118448 creator A5052680269 @default.
• W2105118448 creator A5055069129 @default.
• W2105118448 creator A5066596746 @default.
• W2105118448 creator A5067638427 @default.
• W2105118448 creator A5069502074 @default.
• W2105118448 creator A5070446713 @default.
• W2105118448 creator A5074502655 @default.
• W2105118448 creator A5075501082 @default.
• W2105118448 creator A5079798885 @default.
• W2105118448 creator A5080950140 @default.
• W2105118448 creator A5085736332 @default.
• W2105118448 creator A5088091678 @default.
• W2105118448 creator A5089617818 @default.
• W2105118448 date "2004-11-03" @default.
• W2105118448 modified "2023-10-17" @default.
• W2105118448 title "Differential Genetic Effects of <EMPH TYPE=ITAL>ESR1</EMPH> Gene Polymorphisms on Osteoporosis Outcomes" @default.
• W2105118448 cites W1690786713 @default.
• W2105118448 cites W1965548901 @default.
• W2105118448 cites W1966411863 @default.
• W2105118448 cites W1979804577 @default.
• W2105118448 cites W1990034002 @default.
• W2105118448 cites W1995849174 @default.
• W2105118448 cites W2011398939 @default.
• W2105118448 cites W2012027678 @default.
• W2105118448 cites W2017552465 @default.
• W2105118448 cites W2023173649 @default.
• W2105118448 cites W2024355830 @default.
• W2105118448 cites W2027361451 @default.
• W2105118448 cites W2035153654 @default.
• W2105118448 cites W2036125852 @default.
• W2105118448 cites W2065435420 @default.
• W2105118448 cites W2082233939 @default.
• W2105118448 cites W2091619551 @default.
• W2105118448 cites W2094934696 @default.
• W2105118448 cites W2109921650 @default.
• W2105118448 cites W2110755408 @default.
• W2105118448 cites W2110828193 @default.
• W2105118448 cites W2112339576 @default.
• W2105118448 cites W2123061389 @default.
• W2105118448 cites W2126070576 @default.
• W2105118448 cites W2137432207 @default.
• W2105118448 cites W2146693532 @default.
• W2105118448 cites W2154987378 @default.
• W2105118448 cites W2157355643 @default.
• W2105118448 cites W2162235775 @default.
• W2105118448 cites W2163786945 @default.
• W2105118448 cites W2164374136 @default.
• W2105118448 cites W2166101050 @default.
• W2105118448 cites W2169434689 @default.
• W2105118448 cites W2977262736 @default.
• W2105118448 doi "https://doi.org/10.1001/jama.292.17.2105" @default.
• W2105118448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15523071" @default.
• W2105118448 hasPublicationYear "2004" @default.
• W2105118448 type Work @default.
• W2105118448 sameAs 2105118448 @default.
• W2105118448 citedByCount "284" @default.
• W2105118448 countsByYear W21051184482012 @default.
• W2105118448 countsByYear W21051184482013 @default.
• W2105118448 countsByYear W21051184482014 @default.
• W2105118448 countsByYear W21051184482015 @default.
• W2105118448 countsByYear W21051184482016 @default.
• W2105118448 countsByYear W21051184482017 @default.
• W2105118448 countsByYear W21051184482018 @default.
• W2105118448 countsByYear W21051184482019 @default.
• W2105118448 countsByYear W21051184482020 @default.
• W2105118448 countsByYear W21051184482021 @default.
• W2105118448 countsByYear W21051184482022 @default.
• W2105118448 countsByYear W21051184482023 @default.
• W2105118448 crossrefType "journal-article" @default.
• W2105118448 hasAuthorship W2105118448A5011914418 @default.
• W2105118448 hasAuthorship W2105118448A5016379322 @default.
• W2105118448 hasAuthorship W2105118448A5019607729 @default.
• W2105118448 hasAuthorship W2105118448A5031530236 @default.
• W2105118448 hasAuthorship W2105118448A5033638665 @default.
• W2105118448 hasAuthorship W2105118448A5034668013 @default.
• W2105118448 hasAuthorship W2105118448A5036667571 @default.
• W2105118448 hasAuthorship W2105118448A5037877043 @default.
• W2105118448 hasAuthorship W2105118448A5038891840 @default.
• W2105118448 hasAuthorship W2105118448A5043291392 @default.
• W2105118448 hasAuthorship W2105118448A5043643384 @default.
• W2105118448 hasAuthorship W2105118448A5052229575 @default.
• W2105118448 hasAuthorship W2105118448A5052680269 @default.
• W2105118448 hasAuthorship W2105118448A5055069129 @default.
• W2105118448 hasAuthorship W2105118448A5066596746 @default.

• next