FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105130082> ?p ?o ?g. }

• W2105130082 endingPage "334" @default.
• W2105130082 startingPage "327" @default.
• W2105130082 abstract "Maintenance and achievement of an optimal platelet function by dietary solutions might be considered an interesting target to influence cardiovascular health. Polyphenol-rich foods such as vegetables and fruits have been shown to significantly improve platelet function in ex vivo studies in humans. However, until yet, it still remains unclear if polyphenols itself, their metabolites or a mixture of both are responsible for the beneficial effects observed so far. Our study aims to evaluate the effect of anthocyanins, in vivo metabolites of different polyphenols from colonic origin and a representative mixture of both at physiological concentrations on platelet aggregation and activation function. Some anthocyanins [1 microM], colonic metabolites [10 microM] and a mixture (4 phenolic acid [1 microM], 4 anthocyanin [0.1 microM] showed significant platelet sedating and desensitizing effects. Activation of the platelets (P-selectin expression) was significantly reduced by 10-40% in resting platelets, TRAP-activated and hydrogen peroxide-stressed platelets and epinephrine pre-activated platelets relative to controls. The dose-response curve of the weak agonist TRAP was also significantly altered resulting in a >0.8 microM increase of threshold concentration to induce aggregation. The representative mixture was active despite ten times lower concentrations of the individual components, which showed no activity when tested individually at that concentration, indicating synergism of the different components. Platelet reactivity to strong agonists such as collagen and ADP was not influenced. These results show that anthocyanins and in vivo metabolites of polyphenols have anti-thrombotic properties, suggesting themselves as well as their dietary sources and precursors as potential cardiovascular health promoters." @default.
• W2105130082 created "2016-06-24" @default.
• W2105130082 creator A5033521150 @default.
• W2105130082 creator A5045958512 @default.
• W2105130082 date "2005-01-01" @default.
• W2105130082 modified "2023-10-11" @default.
• W2105130082 title "Anthocyanins and colonic metabolites of dietary polyphenols inhibit platelet function" @default.
• W2105130082 cites W1574451752 @default.
• W2105130082 cites W1849728297 @default.
• W2105130082 cites W1865530734 @default.
• W2105130082 cites W1926222251 @default.
• W2105130082 cites W1967709468 @default.
• W2105130082 cites W1973511125 @default.
• W2105130082 cites W1981145469 @default.
• W2105130082 cites W1984412933 @default.
• W2105130082 cites W1985716651 @default.
• W2105130082 cites W1993464664 @default.
• W2105130082 cites W1998178455 @default.
• W2105130082 cites W2021171647 @default.
• W2105130082 cites W2038768313 @default.
• W2105130082 cites W2041181574 @default.
• W2105130082 cites W2052862118 @default.
• W2105130082 cites W2063765017 @default.
• W2105130082 cites W2063950428 @default.
• W2105130082 cites W2078166953 @default.
• W2105130082 cites W2078301561 @default.
• W2105130082 cites W2080776250 @default.
• W2105130082 cites W2104805509 @default.
• W2105130082 cites W2105234557 @default.
• W2105130082 cites W2120487488 @default.
• W2105130082 cites W2132363861 @default.
• W2105130082 cites W2139399563 @default.
• W2105130082 cites W2152025445 @default.
• W2105130082 cites W2168731440 @default.
• W2105130082 cites W2315528902 @default.
• W2105130082 doi "https://doi.org/10.1016/j.thromres.2005.01.002" @default.
• W2105130082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16038718" @default.
• W2105130082 hasPublicationYear "2005" @default.
• W2105130082 type Work @default.
• W2105130082 sameAs 2105130082 @default.
• W2105130082 citedByCount "197" @default.
• W2105130082 countsByYear W21051300822012 @default.
• W2105130082 countsByYear W21051300822013 @default.
• W2105130082 countsByYear W21051300822014 @default.
• W2105130082 countsByYear W21051300822015 @default.
• W2105130082 countsByYear W21051300822016 @default.
• W2105130082 countsByYear W21051300822017 @default.
• W2105130082 countsByYear W21051300822018 @default.
• W2105130082 countsByYear W21051300822019 @default.
• W2105130082 countsByYear W21051300822020 @default.
• W2105130082 countsByYear W21051300822021 @default.
• W2105130082 countsByYear W21051300822022 @default.
• W2105130082 countsByYear W21051300822023 @default.
• W2105130082 crossrefType "journal-article" @default.
• W2105130082 hasAuthorship W2105130082A5033521150 @default.
• W2105130082 hasAuthorship W2105130082A5045958512 @default.
• W2105130082 hasConcept C126322002 @default.
• W2105130082 hasConcept C150903083 @default.
• W2105130082 hasConcept C185592680 @default.
• W2105130082 hasConcept C202751555 @default.
• W2105130082 hasConcept C207001950 @default.
• W2105130082 hasConcept C26291073 @default.
• W2105130082 hasConcept C2778004101 @default.
• W2105130082 hasConcept C2778945092 @default.
• W2105130082 hasConcept C3018697912 @default.
• W2105130082 hasConcept C31903555 @default.
• W2105130082 hasConcept C55493867 @default.
• W2105130082 hasConcept C70899900 @default.
• W2105130082 hasConcept C71924100 @default.
• W2105130082 hasConcept C86803240 @default.
• W2105130082 hasConcept C89560881 @default.
• W2105130082 hasConcept C98274493 @default.
• W2105130082 hasConceptScore W2105130082C126322002 @default.
• W2105130082 hasConceptScore W2105130082C150903083 @default.
• W2105130082 hasConceptScore W2105130082C185592680 @default.
• W2105130082 hasConceptScore W2105130082C202751555 @default.
• W2105130082 hasConceptScore W2105130082C207001950 @default.
• W2105130082 hasConceptScore W2105130082C26291073 @default.
• W2105130082 hasConceptScore W2105130082C2778004101 @default.
• W2105130082 hasConceptScore W2105130082C2778945092 @default.
• W2105130082 hasConceptScore W2105130082C3018697912 @default.
• W2105130082 hasConceptScore W2105130082C31903555 @default.
• W2105130082 hasConceptScore W2105130082C55493867 @default.
• W2105130082 hasConceptScore W2105130082C70899900 @default.
• W2105130082 hasConceptScore W2105130082C71924100 @default.
• W2105130082 hasConceptScore W2105130082C86803240 @default.
• W2105130082 hasConceptScore W2105130082C89560881 @default.
• W2105130082 hasConceptScore W2105130082C98274493 @default.
• W2105130082 hasIssue "4" @default.
• W2105130082 hasLocation W21051300821 @default.
• W2105130082 hasLocation W21051300822 @default.
• W2105130082 hasOpenAccess W2105130082 @default.
• W2105130082 hasPrimaryLocation W21051300821 @default.
• W2105130082 hasRelatedWork W1988467799 @default.
• W2105130082 hasRelatedWork W2057882783 @default.
• W2105130082 hasRelatedWork W2062077711 @default.
• W2105130082 hasRelatedWork W2378957323 @default.
• W2105130082 hasRelatedWork W2380802782 @default.

• next