Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105138745> ?p ?o ?g. }
- W2105138745 endingPage "772" @default.
- W2105138745 startingPage "766" @default.
- W2105138745 abstract "Although the use of combined oral contraceptives (COCs) is associated with an increased risk of arterial and venous thromboembolic events, less is known about the impact of COCs on endothelial function. The present study evaluated the effects on the endothelium of healthy women of combinations of 30 mcg ethinylestradiol (EE)/2 mg chlormadinone acetate (CMA) and 30 mcg EE/150 mcg levonorgestrel (LNG).Sixty-four healthy women were evaluated, 21 using a nonhormonal contraceptive method (control) and 43 using COCs, randomized to EE 30 mcg /CMA 2 mg or to EE 30 mcg/LNG 150 mcg. Anthropometric parameters, systolic arterial pressure (SAP), diastolic arterial pressure (DAP), ultrasound markers of endothelial function, flow-mediated dilation (FMD) of the brachial artery, intima-media thickness (IMT) and common carotid artery stiffness were measured at randomization and 6 months later.Relative to baseline, EE/CMA users showed a significant reduction in mean DAP at 6 months (p=.02), and EE/LNG users showed a significant increase in mean IMT (p=.02) and a significant reduction in mean FMD (p=.01) at 6 months. DAP at 6 months was significantly lower in COC users than in controls (p=.01). Intergroup evaluations showed that, at 6 months, mean SAP (p=.02) was significantly lower in EE/LNG users than in controls (p=.02) and that mean DAP was significantly lower in EE/CMA (p<.01) and EE/LNG (p=.01) users than in controls. EE/LNG users experienced a mean FMD reduction almost threefold greater than that of EE/CMA users. Compared to controls, EE/LNG users experienced a 7.5-fold greater reduction in mean FMD.COC containing LNG is associated with more pronounced changes in the FMD and IMT of healthy women than a COC containing CMA and nonhormonal contraception. Further studies are needed to determine whether these differences may lead to higher risk of arterial thromboembolic events." @default.
- W2105138745 created "2016-06-24" @default.
- W2105138745 creator A5006731547 @default.
- W2105138745 creator A5052395996 @default.
- W2105138745 creator A5061927543 @default.
- W2105138745 creator A5073772720 @default.
- W2105138745 creator A5088652649 @default.
- W2105138745 date "2013-06-01" @default.
- W2105138745 modified "2023-09-26" @default.
- W2105138745 title "Effects of combined oral contraceptives containing levonorgestrel or chlormadinone on the endothelium" @default.
- W2105138745 cites W122349615 @default.
- W2105138745 cites W129778488 @default.
- W2105138745 cites W1555489744 @default.
- W2105138745 cites W1733498604 @default.
- W2105138745 cites W1959800866 @default.
- W2105138745 cites W1966047575 @default.
- W2105138745 cites W1978932718 @default.
- W2105138745 cites W1985949705 @default.
- W2105138745 cites W1994755189 @default.
- W2105138745 cites W1998181443 @default.
- W2105138745 cites W1999011481 @default.
- W2105138745 cites W2004915770 @default.
- W2105138745 cites W2013765695 @default.
- W2105138745 cites W2014231512 @default.
- W2105138745 cites W2039826532 @default.
- W2105138745 cites W2040435126 @default.
- W2105138745 cites W2040825399 @default.
- W2105138745 cites W2059461238 @default.
- W2105138745 cites W2063506869 @default.
- W2105138745 cites W2065506286 @default.
- W2105138745 cites W2065987587 @default.
- W2105138745 cites W2072751592 @default.
- W2105138745 cites W2076037018 @default.
- W2105138745 cites W2080998658 @default.
- W2105138745 cites W2092562078 @default.
- W2105138745 cites W2093824802 @default.
- W2105138745 cites W2095415077 @default.
- W2105138745 cites W2107663432 @default.
- W2105138745 cites W2125762197 @default.
- W2105138745 cites W2128055881 @default.
- W2105138745 cites W2135154799 @default.
- W2105138745 cites W2137491995 @default.
- W2105138745 cites W2141630022 @default.
- W2105138745 cites W2141665762 @default.
- W2105138745 cites W2144795879 @default.
- W2105138745 cites W2145974818 @default.
- W2105138745 cites W2146576387 @default.
- W2105138745 cites W2162876271 @default.
- W2105138745 cites W2168509987 @default.
- W2105138745 cites W2181590274 @default.
- W2105138745 cites W4256605237 @default.
- W2105138745 cites W815493730 @default.
- W2105138745 doi "https://doi.org/10.1016/j.contraception.2012.09.023" @default.
- W2105138745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23102798" @default.
- W2105138745 hasPublicationYear "2013" @default.
- W2105138745 type Work @default.
- W2105138745 sameAs 2105138745 @default.
- W2105138745 citedByCount "13" @default.
- W2105138745 countsByYear W21051387452015 @default.
- W2105138745 countsByYear W21051387452016 @default.
- W2105138745 countsByYear W21051387452017 @default.
- W2105138745 countsByYear W21051387452019 @default.
- W2105138745 countsByYear W21051387452020 @default.
- W2105138745 countsByYear W21051387452021 @default.
- W2105138745 countsByYear W21051387452023 @default.
- W2105138745 crossrefType "journal-article" @default.
- W2105138745 hasAuthorship W2105138745A5006731547 @default.
- W2105138745 hasAuthorship W2105138745A5052395996 @default.
- W2105138745 hasAuthorship W2105138745A5061927543 @default.
- W2105138745 hasAuthorship W2105138745A5073772720 @default.
- W2105138745 hasAuthorship W2105138745A5088652649 @default.
- W2105138745 hasConcept C126322002 @default.
- W2105138745 hasConcept C134018914 @default.
- W2105138745 hasConcept C2777604165 @default.
- W2105138745 hasConcept C2777956591 @default.
- W2105138745 hasConcept C2778239997 @default.
- W2105138745 hasConcept C2779076696 @default.
- W2105138745 hasConcept C2780146029 @default.
- W2105138745 hasConcept C2780186607 @default.
- W2105138745 hasConcept C2908647359 @default.
- W2105138745 hasConcept C29456083 @default.
- W2105138745 hasConcept C2986740045 @default.
- W2105138745 hasConcept C2986817661 @default.
- W2105138745 hasConcept C71924100 @default.
- W2105138745 hasConcept C84393581 @default.
- W2105138745 hasConcept C99454951 @default.
- W2105138745 hasConceptScore W2105138745C126322002 @default.
- W2105138745 hasConceptScore W2105138745C134018914 @default.
- W2105138745 hasConceptScore W2105138745C2777604165 @default.
- W2105138745 hasConceptScore W2105138745C2777956591 @default.
- W2105138745 hasConceptScore W2105138745C2778239997 @default.
- W2105138745 hasConceptScore W2105138745C2779076696 @default.
- W2105138745 hasConceptScore W2105138745C2780146029 @default.
- W2105138745 hasConceptScore W2105138745C2780186607 @default.
- W2105138745 hasConceptScore W2105138745C2908647359 @default.
- W2105138745 hasConceptScore W2105138745C29456083 @default.
- W2105138745 hasConceptScore W2105138745C2986740045 @default.
- W2105138745 hasConceptScore W2105138745C2986817661 @default.