FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105145945> ?p ?o ?g. }

• W2105145945 endingPage "36" @default.
• W2105145945 startingPage "28" @default.
• W2105145945 abstract "Diallyl sulfide (DAS), a naturally occurring organosulfide, present in garlic, is known to possess pleiotropic biological effects. DAS is known to inhibit chemically induced tumors in a number of animal models. The chemopreventive properties of DAS seem to occur through a number of mechanisms, but its role on primary events on oncogenic activation is not well understood. In the present study, we demonstrated the modulatory effect of DAS on the expression of H-ras gene product, p21/ras protein as one of the mechanisms of its chemopreventive action in chemically induced mouse skin tumors. Our results showed that DAS administration leads to modulation of the DMBA-induced levels of p21/ras oncoprotein as early as 24 h after the DMBA application, suggesting down-regulation of the p21/ras by DAS. Furthermore, the modulatory effects of DAS were also evident in DMBA-induced mouse skin tumors. DAS administration led to increase in the levels of cytosolic p21/ras and decrease in the levels of p21/ras in membrane fractions. DAS administration was also found to down regulate the DMBA-induced H-ras mRNA level in mouse skin tumors. The immunohistochemical staining of the skin/tumor showed 55.82 and 46.86% decrease in the area positive for p21/ras expression levels in DAS pre- and post-supplemented groups, respectively. Flow-cytometric analysis, further confirms our results as indicated by a shift in the mean fluorescence intensity (MFI) towards lower fluorescence in DAS administered groups in comparison to the DMBA treated group. Thus, one mechanism of the growth inhibitory properties of DAS is through the suppression of development of tumors that harbor ras mutations by inhibiting the membrane association of oncogenic p21/ras protein." @default.
• W2105145945 created "2016-06-24" @default.
• W2105145945 creator A5025606522 @default.
• W2105145945 creator A5057763339 @default.
• W2105145945 creator A5086891043 @default.
• W2105145945 date "2006-10-01" @default.
• W2105145945 modified "2023-09-27" @default.
• W2105145945 title "Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin" @default.
• W2105145945 cites W103445271 @default.
• W2105145945 cites W1522954291 @default.
• W2105145945 cites W1775749144 @default.
• W2105145945 cites W1939968253 @default.
• W2105145945 cites W1985651419 @default.
• W2105145945 cites W1992907029 @default.
• W2105145945 cites W1994757654 @default.
• W2105145945 cites W2005041472 @default.
• W2105145945 cites W2016727129 @default.
• W2105145945 cites W2017098460 @default.
• W2105145945 cites W2031556743 @default.
• W2105145945 cites W2031743881 @default.
• W2105145945 cites W2034994712 @default.
• W2105145945 cites W2036581624 @default.
• W2105145945 cites W2045553710 @default.
• W2105145945 cites W2049296953 @default.
• W2105145945 cites W2061128317 @default.
• W2105145945 cites W2076578505 @default.
• W2105145945 cites W2080719056 @default.
• W2105145945 cites W2086589373 @default.
• W2105145945 cites W2087541185 @default.
• W2105145945 cites W2101108802 @default.
• W2105145945 cites W2101277805 @default.
• W2105145945 cites W2140998607 @default.
• W2105145945 cites W2152583644 @default.
• W2105145945 cites W2153435788 @default.
• W2105145945 cites W2161710239 @default.
• W2105145945 cites W2171138151 @default.
• W2105145945 cites W2185032406 @default.
• W2105145945 cites W2322393452 @default.
• W2105145945 cites W33164264 @default.
• W2105145945 doi "https://doi.org/10.1016/j.canlet.2005.10.049" @default.
• W2105145945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16448747" @default.
• W2105145945 hasPublicationYear "2006" @default.
• W2105145945 type Work @default.
• W2105145945 sameAs 2105145945 @default.
• W2105145945 citedByCount "34" @default.
• W2105145945 countsByYear W21051459452012 @default.
• W2105145945 countsByYear W21051459452013 @default.
• W2105145945 countsByYear W21051459452014 @default.
• W2105145945 countsByYear W21051459452016 @default.
• W2105145945 countsByYear W21051459452018 @default.
• W2105145945 countsByYear W21051459452019 @default.
• W2105145945 countsByYear W21051459452020 @default.
• W2105145945 countsByYear W21051459452021 @default.
• W2105145945 countsByYear W21051459452022 @default.
• W2105145945 countsByYear W21051459452023 @default.
• W2105145945 crossrefType "journal-article" @default.
• W2105145945 hasAuthorship W2105145945A5025606522 @default.
• W2105145945 hasAuthorship W2105145945A5057763339 @default.
• W2105145945 hasAuthorship W2105145945A5086891043 @default.
• W2105145945 hasConcept C104317684 @default.
• W2105145945 hasConcept C114246631 @default.
• W2105145945 hasConcept C153911025 @default.
• W2105145945 hasConcept C185592680 @default.
• W2105145945 hasConcept C203014093 @default.
• W2105145945 hasConcept C204232928 @default.
• W2105145945 hasConcept C2778938436 @default.
• W2105145945 hasConcept C502942594 @default.
• W2105145945 hasConcept C55493867 @default.
• W2105145945 hasConcept C555283112 @default.
• W2105145945 hasConcept C86803240 @default.
• W2105145945 hasConceptScore W2105145945C104317684 @default.
• W2105145945 hasConceptScore W2105145945C114246631 @default.
• W2105145945 hasConceptScore W2105145945C153911025 @default.
• W2105145945 hasConceptScore W2105145945C185592680 @default.
• W2105145945 hasConceptScore W2105145945C203014093 @default.
• W2105145945 hasConceptScore W2105145945C204232928 @default.
• W2105145945 hasConceptScore W2105145945C2778938436 @default.
• W2105145945 hasConceptScore W2105145945C502942594 @default.
• W2105145945 hasConceptScore W2105145945C55493867 @default.
• W2105145945 hasConceptScore W2105145945C555283112 @default.
• W2105145945 hasConceptScore W2105145945C86803240 @default.
• W2105145945 hasIssue "1" @default.
• W2105145945 hasLocation W21051459451 @default.
• W2105145945 hasLocation W21051459452 @default.
• W2105145945 hasOpenAccess W2105145945 @default.
• W2105145945 hasPrimaryLocation W21051459451 @default.
• W2105145945 hasRelatedWork W1968237599 @default.
• W2105145945 hasRelatedWork W2030512213 @default.
• W2105145945 hasRelatedWork W2033561085 @default.
• W2105145945 hasRelatedWork W2040948297 @default.
• W2105145945 hasRelatedWork W2068720129 @default.
• W2105145945 hasRelatedWork W2147521894 @default.
• W2105145945 hasRelatedWork W2183471953 @default.
• W2105145945 hasRelatedWork W2412566152 @default.
• W2105145945 hasRelatedWork W277309215 @default.
• W2105145945 hasRelatedWork W1521881692 @default.
• W2105145945 hasVolume "242" @default.
• W2105145945 isParatext "false" @default.

• next