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- W210515338 endingPage "294" @default.
- W210515338 startingPage "265" @default.
- W210515338 abstract "The central nervous system (CNS) is extremely vulnerable to ischemia. In humans, the brain accounts for approx 2% of body weight, but receives about 15% of cardiac output. The amounts of energy metabolites (glucose and glycogen) and oxygen stored in the brain are so small that cessation of blood supply for only a few minutes leads to severe CNS damage. This vulnerability of the CNS mainly derives from the vulnerability of neurons, the major component of the CNS. Therefore, many therapeutic modalities have been developed to protect neurons from ischemic damage. In this sense, cultured neurons (in vitro model) are enough to test the efficacy of a therapy. However, the results of such tests indicate only the level of cytotoxicity of a therapy. The cultured neurons never show neurological deficits. Ischemic insult to the human CNS may lead to a wide variety of signs and symptoms, from death to very slight neurological deficits. Rational therapies for cerebral ischemia should be established on a detailed understanding of the pathomechanisms involved. This is why we need experimental stroke models." @default.
- W210515338 created "2016-06-24" @default.
- W210515338 creator A5005634038 @default.
- W210515338 creator A5012443421 @default.
- W210515338 creator A5090428332 @default.
- W210515338 date "1997-01-01" @default.
- W210515338 modified "2023-09-27" @default.
- W210515338 title "Animal Models Used in Cerebral Ischemia and Stroke Research" @default.
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