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• W2105154097 startingPage "131" @default.
• W2105154097 abstract "Background : There has been a growing interest in treating postmenopausal women with androgens. However, hyperandrogenemia in females has been associated with increased risk of cardiovascular disease. Objective : We aimed to assess the effects of androgen replacement on cardiovascular risk factors. Design : Thirty-seven postmenopausal women aged 42–62 years that had undergone hysterectomy were prospectively enrolled in a double-blind protocol to receive, for 12 months, percutaneous estradiol (E 2 ) (1 mg/day) combined with either methyltestosterone (MT) (1.25 mg/day) or placebo. Methods : Along with treatment, we evaluated serum E 2 , testosterone, sex hormone-binding globulin (SHBG), free androgen index, lipids, fibrinogen, and C-reactive protein; glucose tolerance; insulin resistance; blood pressure; body-mass index; and visceral and subcutaneous abdominal fat mass as assessed by computed tomography. Results : A significant reduction in SHBG ( P < 0.001) and increase in free testosterone index ( P < 0.05; Repeated measures analysis of variance) were seen in the MT group. Total cholesterol, triglycerides, fibrinogen, and systolic and diastolic blood pressure were significantly lowered to a similar extent by both regimens, but high-density lipoprotein cholesterol decreased only in the androgen group. MT-treated women showed a modest rise in body weight and gained visceral fat mass relative to the other group ( P < 0.05), but there were no significant detrimental effects on fasting insulin levels and insulin resistance. Conclusion : This study suggests that the combination of low-dose oral MT and percutaneous E 2 , for 1 year, does not result in expressive increase of cardiovascular risk factors. This regimen can be recommended for symptomatic postmenopausal women, although it seems prudent to perform baseline and follow-up lipid profile and assessment of body composition, especially in those at high risk of cardiovascular disease." @default.
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• W2105154097 date "2006-01-01" @default.
• W2105154097 modified "2023-10-15" @default.
• W2105154097 title "Influence of methyltestosterone postmenopausal therapy on plasma lipids, inflammatory factors, glucose metabolism and visceral fat: a randomized study" @default.
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• W2105154097 doi "https://doi.org/10.1530/eje.1.02065" @default.
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