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• W2105164003 abstract "The pharmacokinetic properties of ceftriaxone, a third‐generation cephalosporin, were investigated in five cats after single intravenous, intramuscular and subcutaneous administration at a dosage of 25 mg/kg. Ceftriaxone MIC s for some gram‐negative and positive strains isolated from clinical cases were determined. Efficacy predictor ( t > MIC ) was calculated. Serum ceftriaxone disposition was best fitted by a bicompartmental and a monocompartmental open models with first‐order elimination after intravenous and intramuscular and subcutaneous dosing, respectively. After intravenous administration, distribution was fast ( t 1/2d 0.14 ± 0.02 h) and moderate as reflected by the volume of distribution ( V d(ss) ) of 0.57 ± 0.22 L/kg. Furthermore, elimination was rapid with a plasma clearance of 0.37 ± 0.13 L/h·kg and a t 1/2 of 1.73 ± 0.23 h. Peak serum concentration ( C max ), t max and bioavailability for the intramuscular administration were 54.40 ± 12.92 μ g/mL, 0.33 ± 0.07 h and 85.72 ± 14.74%, respectively; and for the subcutaneous route the same parameters were 42.35 ± 17.62 μ g/mL, 1.27 ± 0.95 h and 118.28 ± 39.17%. Ceftriaxone MIC for gram‐negative bacteria ranged from 0.0039 to >8 μ g/mL and for gram‐positive bacteria from 0.5 to 4 μ g/mL. t > MIC was in the range 83.31–91.66% (10–12 h) of the recommended dosing interval (12 h) for Escherichia coli ( MIC 90 = 0.2 μ g/mL)." @default.
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• W2105164003 date "2007-05-30" @default.
• W2105164003 modified "2023-10-16" @default.
• W2105164003 title "Pharmacokinetics of ceftriaxone after intravenous, intramuscular and subcutaneous administration to domestic cats" @default.
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• W2105164003 doi "https://doi.org/10.1111/j.1365-2885.2007.00871.x" @default.
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