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• W2105173404 abstract "Abstract Purpose: Serum levels of the inflammatory markers YKL-40 and interleukin 6 (IL-6) are increased in many conditions, including cancers. We examined serum YKL-40 and IL-6 levels in patients with Hodgkin lymphoma, a tumor with strong immunologic reaction to relatively few tumor cells, especially in nodular sclerosis Hodgkin lymphoma. Experimental Design: We analyzed Danish and Swedish patients with incident Hodgkin lymphoma (N = 470) and population controls from Denmark (n = 245 for YKL-40; n = 348 for IL-6). Serum YKL-40 and IL-6 levels were determined by ELISA, and log-transformed data were analyzed by linear regression, adjusting for age and sex. Results: Serum levels of YKL-40 and IL-6 increased in Hodgkin lymphoma patients compared with controls (YKL-40, 3.6-fold; IL-6, 8.3-fold; both, P &lt; 0.0001). In pretreatment samples from pretreatment Hodgkin lymphoma patients (n = 176), levels were correlated with more advanced stages (Ptrend, 0.0001 for YKL-40 and 0.013 for IL-6) and in those with B symptoms; however, levels were similar in nodular sclerosis and mixed cellularity subtypes, by EBV status, and in younger (&lt;45 years old) and older patients. Patients tested soon after treatment onset had significantly lower levels than pretreatment patients; however, even ≥6 months after treatment onset, serum YKL-40 and IL-6 levels remained significantly increased compared with controls. In patients who died (n = 12), pretreatment levels for YKL-40 and IL-6 were higher than in survivors, although not statistically significantly. Conclusions: Serum YKL-40 and IL-6 levels were increased in untreated Hodgkin lymphoma patients and those with more advanced stages but did not differ significantly by Hodgkin lymphoma histology. Following treatment, serum levels were significantly lower." @default.
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• W2105173404 date "2008-11-01" @default.
• W2105173404 modified "2023-10-10" @default.
• W2105173404 title "Serum YKL-40 and Interleukin 6 Levels in Hodgkin Lymphoma" @default.
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• W2105173404 doi "https://doi.org/10.1158/1078-0432.ccr-08-1026" @default.
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