FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105188644> ?p ?o ?g. }

• W2105188644 endingPage "268" @default.
• W2105188644 startingPage "260" @default.
• W2105188644 abstract "Trans-sialidases catalyze the transfer of a sialic acid from one sialoside to an acceptor to form a new sialoside. alpha2,3-Trans-sialidase activity was initially discovered in the parasitic protozoan Trypanosoma cruzi, and more recently was found in a multifunctional Pasteurella multocida sialyltransferase PmST1. alpha2,8-Trans-sialidase activity was also described for a multifunctional Campylobacter jejuni sialyltransferase CstII. We report here the discovery of the alpha2,6-trans-sialidase activity of a previously reported recombinant truncated bacterial alpha2,6-sialyltransferase from Photobacterium damsela (Delta15Pd2,6ST). This is the first time that the alpha2,6-trans-sialidase activity has ever been identified. Kinetic studies indicate that Delta15Pd2,6ST-catalyzed trans-sialidase reaction follows a ping-pong bi-bi reaction mechanism. Cytidine 5'-monophosphate, the product of sialyltransferase reactions, is not required by the trans-sialidase activity of the enzyme but enhances the trans-sialidase activity modestly as a non-essential activator. Using chemically synthesized Neu5AcalphapNP and LacbetaMU, alpha2,6-linked sialoside Neu5Acalpha2,6LacbetaMU has been obtained in one-step in high yield using the trans-sialidase activity of Delta15Pd2,6ST. In addition to the alpha2,6-trans-sialidase activity, Delta15Pd2,6ST also has alpha2,6-sialidase activity. The multifunctionality is thus a common feature of many bacterial sialyltransferases." @default.
• W2105188644 created "2016-06-24" @default.
• W2105188644 creator A5005509086 @default.
• W2105188644 creator A5008171524 @default.
• W2105188644 creator A5018882725 @default.
• W2105188644 creator A5030596631 @default.
• W2105188644 creator A5057481154 @default.
• W2105188644 creator A5064435064 @default.
• W2105188644 date "2009-10-30" @default.
• W2105188644 modified "2023-09-26" @default.
• W2105188644 title "Trans-sialidase activity of Photobacterium damsela 2,6-sialyltransferase and its application in the synthesis of sialosides" @default.
• W2105188644 cites W1574167776 @default.
• W2105188644 cites W1580259448 @default.
• W2105188644 cites W1912870130 @default.
• W2105188644 cites W1968683690 @default.
• W2105188644 cites W1975886691 @default.
• W2105188644 cites W1977950017 @default.
• W2105188644 cites W1983416562 @default.
• W2105188644 cites W1989730031 @default.
• W2105188644 cites W2002534697 @default.
• W2105188644 cites W2009564804 @default.
• W2105188644 cites W2019956004 @default.
• W2105188644 cites W2024254387 @default.
• W2105188644 cites W2030387680 @default.
• W2105188644 cites W2036735538 @default.
• W2105188644 cites W2040225728 @default.
• W2105188644 cites W2041285511 @default.
• W2105188644 cites W2044680673 @default.
• W2105188644 cites W2046589016 @default.
• W2105188644 cites W2062474897 @default.
• W2105188644 cites W2071565903 @default.
• W2105188644 cites W2072256038 @default.
• W2105188644 cites W2077731315 @default.
• W2105188644 cites W2079284158 @default.
• W2105188644 cites W2086586283 @default.
• W2105188644 cites W2114355411 @default.
• W2105188644 cites W2115280713 @default.
• W2105188644 cites W2123256952 @default.
• W2105188644 cites W2137015675 @default.
• W2105188644 cites W2153604498 @default.
• W2105188644 cites W2158297972 @default.
• W2105188644 cites W2161746138 @default.
• W2105188644 cites W2165262749 @default.
• W2105188644 cites W2165956995 @default.
• W2105188644 cites W2168470451 @default.
• W2105188644 cites W2168782275 @default.
• W2105188644 cites W95293157 @default.
• W2105188644 doi "https://doi.org/10.1093/glycob/cwp172" @default.
• W2105188644 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2800248" @default.
• W2105188644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19880425" @default.
• W2105188644 hasPublicationYear "2009" @default.
• W2105188644 type Work @default.
• W2105188644 sameAs 2105188644 @default.
• W2105188644 citedByCount "54" @default.
• W2105188644 countsByYear W21051886442012 @default.
• W2105188644 countsByYear W21051886442013 @default.
• W2105188644 countsByYear W21051886442014 @default.
• W2105188644 countsByYear W21051886442015 @default.
• W2105188644 countsByYear W21051886442016 @default.
• W2105188644 countsByYear W21051886442017 @default.
• W2105188644 countsByYear W21051886442018 @default.
• W2105188644 countsByYear W21051886442019 @default.
• W2105188644 countsByYear W21051886442020 @default.
• W2105188644 countsByYear W21051886442021 @default.
• W2105188644 countsByYear W21051886442022 @default.
• W2105188644 countsByYear W21051886442023 @default.
• W2105188644 crossrefType "journal-article" @default.
• W2105188644 hasAuthorship W2105188644A5005509086 @default.
• W2105188644 hasAuthorship W2105188644A5008171524 @default.
• W2105188644 hasAuthorship W2105188644A5018882725 @default.
• W2105188644 hasAuthorship W2105188644A5030596631 @default.
• W2105188644 hasAuthorship W2105188644A5057481154 @default.
• W2105188644 hasAuthorship W2105188644A5064435064 @default.
• W2105188644 hasBestOaLocation W21051886441 @default.
• W2105188644 hasConcept C134164806 @default.
• W2105188644 hasConcept C181199279 @default.
• W2105188644 hasConcept C185592680 @default.
• W2105188644 hasConcept C2778322149 @default.
• W2105188644 hasConcept C2778643871 @default.
• W2105188644 hasConcept C2780115458 @default.
• W2105188644 hasConcept C523546767 @default.
• W2105188644 hasConcept C54355233 @default.
• W2105188644 hasConcept C55493867 @default.
• W2105188644 hasConcept C73695083 @default.
• W2105188644 hasConcept C86803240 @default.
• W2105188644 hasConceptScore W2105188644C134164806 @default.
• W2105188644 hasConceptScore W2105188644C181199279 @default.
• W2105188644 hasConceptScore W2105188644C185592680 @default.
• W2105188644 hasConceptScore W2105188644C2778322149 @default.
• W2105188644 hasConceptScore W2105188644C2778643871 @default.
• W2105188644 hasConceptScore W2105188644C2780115458 @default.
• W2105188644 hasConceptScore W2105188644C523546767 @default.
• W2105188644 hasConceptScore W2105188644C54355233 @default.
• W2105188644 hasConceptScore W2105188644C55493867 @default.
• W2105188644 hasConceptScore W2105188644C73695083 @default.
• W2105188644 hasConceptScore W2105188644C86803240 @default.
• W2105188644 hasIssue "2" @default.
• W2105188644 hasLocation W21051886441 @default.

• next