FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105190639> ?p ?o ?g. }

• W2105190639 endingPage "8728" @default.
• W2105190639 startingPage "8713" @default.
• W2105190639 abstract "By assessing the contribution of deregulated E2F activity to erythroid defects in Rb null mice, we have identified E2f-2 as being upregulated in end-stage red cells, where we show it is the major pRb-associated E2f and the predominant E2f detected at key target gene promoters. Consistent with its expression pattern, E2f-2 loss restored terminal erythroid maturation to Rb null red cells, including the ability to undergo enucleation. Deletion of E2f-2 also extended the life span of Rb null mice despite persistent defects in placental development, indicating that deregulated E2f-2 activity in differentiating erythroblasts contributes to the premature lethality of Rb null mice. We show that the aberrant entry of Rb null erythroblasts into S phase at times in differentiation when wild-type erythroblasts are exiting the cell cycle is inhibited by E2f-2 deletion. E2f-2 loss induced cell cycle arrest in both wild-type and Rb null erythroblasts and was associated with increased DNA double-strand breaks. These results implicate deregulated E2f-2 in the cell cycle defects observed in Rb null erythroblasts and reveal a novel role for E2f-2 during terminal red blood cell differentiation. The identification of a tissue-restricted role for E2f-2 in erythropoiesis highlights the nonredundant nature of E2f transcription factor activities in cell growth and differentiation." @default.
• W2105190639 created "2016-06-24" @default.
• W2105190639 creator A5039704514 @default.
• W2105190639 creator A5064875740 @default.
• W2105190639 creator A5070881090 @default.
• W2105190639 date "2007-12-01" @default.
• W2105190639 modified "2023-09-27" @default.
• W2105190639 title "Deregulated E2f-2 Underlies Cell Cycle and Maturation Defects in Retinoblastoma Null Erythroblasts" @default.
• W2105190639 cites W1497251274 @default.
• W2105190639 cites W1520563041 @default.
• W2105190639 cites W153782837 @default.
• W2105190639 cites W1609607086 @default.
• W2105190639 cites W1965466808 @default.
• W2105190639 cites W1970331851 @default.
• W2105190639 cites W1981391513 @default.
• W2105190639 cites W1983148799 @default.
• W2105190639 cites W1984328656 @default.
• W2105190639 cites W1989129860 @default.
• W2105190639 cites W1990240568 @default.
• W2105190639 cites W1995979905 @default.
• W2105190639 cites W1996567457 @default.
• W2105190639 cites W1999184263 @default.
• W2105190639 cites W2009214757 @default.
• W2105190639 cites W2016616330 @default.
• W2105190639 cites W2022272502 @default.
• W2105190639 cites W2036455969 @default.
• W2105190639 cites W2037703366 @default.
• W2105190639 cites W2038173255 @default.
• W2105190639 cites W2042717737 @default.
• W2105190639 cites W2057925288 @default.
• W2105190639 cites W2065343028 @default.
• W2105190639 cites W2071427066 @default.
• W2105190639 cites W2072453311 @default.
• W2105190639 cites W2074351462 @default.
• W2105190639 cites W2075279572 @default.
• W2105190639 cites W2082867992 @default.
• W2105190639 cites W2105190923 @default.
• W2105190639 cites W2106157678 @default.
• W2105190639 cites W2107769896 @default.
• W2105190639 cites W2109829350 @default.
• W2105190639 cites W2111142380 @default.
• W2105190639 cites W2115266888 @default.
• W2105190639 cites W2117455358 @default.
• W2105190639 cites W2123240514 @default.
• W2105190639 cites W2130307435 @default.
• W2105190639 cites W2132526380 @default.
• W2105190639 cites W2141712789 @default.
• W2105190639 cites W2144691110 @default.
• W2105190639 cites W2148474812 @default.
• W2105190639 cites W2166668167 @default.
• W2105190639 cites W2791873134 @default.
• W2105190639 cites W3719606 @default.
• W2105190639 cites W3142959081 @default.
• W2105190639 doi "https://doi.org/10.1128/mcb.01118-07" @default.
• W2105190639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2169398" @default.
• W2105190639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17923680" @default.
• W2105190639 hasPublicationYear "2007" @default.
• W2105190639 type Work @default.
• W2105190639 sameAs 2105190639 @default.
• W2105190639 citedByCount "52" @default.
• W2105190639 countsByYear W21051906392012 @default.
• W2105190639 countsByYear W21051906392013 @default.
• W2105190639 countsByYear W21051906392014 @default.
• W2105190639 countsByYear W21051906392015 @default.
• W2105190639 countsByYear W21051906392016 @default.
• W2105190639 countsByYear W21051906392017 @default.
• W2105190639 countsByYear W21051906392022 @default.
• W2105190639 crossrefType "journal-article" @default.
• W2105190639 hasAuthorship W2105190639A5039704514 @default.
• W2105190639 hasAuthorship W2105190639A5064875740 @default.
• W2105190639 hasAuthorship W2105190639A5070881090 @default.
• W2105190639 hasBestOaLocation W21051906392 @default.
• W2105190639 hasConcept C104317684 @default.
• W2105190639 hasConcept C121853132 @default.
• W2105190639 hasConcept C126322002 @default.
• W2105190639 hasConcept C1491633281 @default.
• W2105190639 hasConcept C153911025 @default.
• W2105190639 hasConcept C2776062698 @default.
• W2105190639 hasConcept C2778248108 @default.
• W2105190639 hasConcept C2779703530 @default.
• W2105190639 hasConcept C29537977 @default.
• W2105190639 hasConcept C54355233 @default.
• W2105190639 hasConcept C71924100 @default.
• W2105190639 hasConcept C83258922 @default.
• W2105190639 hasConcept C86803240 @default.
• W2105190639 hasConcept C95444343 @default.
• W2105190639 hasConceptScore W2105190639C104317684 @default.
• W2105190639 hasConceptScore W2105190639C121853132 @default.
• W2105190639 hasConceptScore W2105190639C126322002 @default.
• W2105190639 hasConceptScore W2105190639C1491633281 @default.
• W2105190639 hasConceptScore W2105190639C153911025 @default.
• W2105190639 hasConceptScore W2105190639C2776062698 @default.
• W2105190639 hasConceptScore W2105190639C2778248108 @default.
• W2105190639 hasConceptScore W2105190639C2779703530 @default.
• W2105190639 hasConceptScore W2105190639C29537977 @default.
• W2105190639 hasConceptScore W2105190639C54355233 @default.
• W2105190639 hasConceptScore W2105190639C71924100 @default.
• W2105190639 hasConceptScore W2105190639C83258922 @default.

• next