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• W2105193785 startingPage "R1833" @default.
• W2105193785 abstract "During daily torpor in the dwarf Siberian hamster, Phodopus sungorus, metabolic rate is reduced by 65% compared with the basal rate, but the mechanisms involved are contentious. We examined liver mitochondrial respiration to determine the possible role of active regulated changes and passive thermal effects in the reduction of metabolic rate. When assayed at 37°C, state 3 (phosphorylating) respiration, but not state 4 (nonphosphorylating) respiration, was significantly lower during torpor compared with normothermia, suggesting that active regulated changes occur during daily torpor. Using top-down elasticity analysis, we determined that these active changes in torpor included a reduced substrate oxidation capacity and an increased proton conductance of the inner mitochondrial membrane. At 15°C, mitochondrial respiration was at least 75% lower than at 37°C, but there was no difference between normothermia and torpor. This implies that the active regulated changes are likely more important for reducing respiration at high temperatures (i.e., during entrance) and/or have effects other than reducing respiration at low temperatures. The decrease in respiration from 37°C to 15°C resulted predominantly from a considerable reduction of substrate oxidation capacity in both torpid and normothermic animals. Temperature-dependent changes in proton leak and phosphorylation kinetics depended on metabolic state; proton leakiness increased in torpid animals but decreased in normothermic animals, whereas phosphorylation activity decreased in torpid animals but increased in normothermic animals. Overall, we have shown that both active and passive changes to oxidative phosphorylation occur during daily torpor in this species, contributing to reduced metabolic rate." @default.
• W2105193785 created "2016-06-24" @default.
• W2105193785 creator A5015584287 @default.
• W2105193785 creator A5058156211 @default.
• W2105193785 creator A5082077392 @default.
• W2105193785 date "2007-11-01" @default.
• W2105193785 modified "2023-10-16" @default.
• W2105193785 title "Mitochondrial metabolism during daily torpor in the dwarf Siberian hamster: role of active regulated changes and passive thermal effects" @default.
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• W2105193785 doi "https://doi.org/10.1152/ajpregu.00310.2007" @default.
• W2105193785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17804585" @default.
• W2105193785 hasPublicationYear "2007" @default.
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