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- W2105202351 abstract "Although atrial fibrillation (AF) represents the most common arrhythmia that is seen in every day cardiology practice,1–3 the surgeons, and not the cardiologists, were the first to take the initiative for its radical cure. Cox and colleagues4,5 developed the Maze procedure and its modifications in the 80s followed by the pioneering attempt of Swartz et al .6 to ablate the arrhythmia in the electrophysiology laboratory in 1994. Now, catheter ablation is an established therapeutic option for certain patients with AF. Several ablation strategies have emerged which, although extremely diverse, report similar success rates, in the range of 60–80%, with 30–40% of patients followed for a year or two having had two procedures, however, different endpoints and methodology of assessment of AF recurrence make interpretation of success rather difficult.7 It is of interest that despite the considerable clinical experience and accumulated evidence from experimental data, the exact mechanism of eliminating AF by catheter ablation techniques is still unknown.Since the seminal studies by Haissaguerre’s group,8 the effectiveness of segmental ablation at the ostia of the pulmonary veins (PV) has been demonstrated in several reports. There is substantial evidence that isolation of the PV, either by ostial or circumferential radiofrequency lesions, removes a potential source of arrhythmia that initiates and perpetuates AF. Although re-emergence of AF following PV disconnection procedures is usually due to recurrence of PV conduction,9–11 complete electrical isolation of the PVs may not be necessary for a successful outcome.10,12–16 Recurrence of PV conduction following complete PV isolation may occur in up to 98% of PVs and may not indicate a propensity to arrhythmia.16 Thus, recurrence of AF following ablation indicates recurrence of PV conduction, but the opposite is not always true. … *Corresponding author. Tel: +30 210 6416600; fax: +30 210 6416661. E-mail address : dkatritsis{at}euroclinic.gr" @default.
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- W2105202351 date "2007-10-03" @default.
- W2105202351 modified "2023-09-26" @default.
- W2105202351 title "Catheter ablation of atrial fibrillation: do we know what we are doing?" @default.
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- W2105202351 doi "https://doi.org/10.1093/europace/eum171" @default.
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- W2105202351 hasPublicationYear "2007" @default.
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