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- W2105203462 abstract "We showed previously that TRH down-regulates TRH receptor (TRH-R) mRNA in GH3 cells by a mechanism that appears to be mediated by protein kinase C. Here we show that vasoactive intestinal peptide (VIP) down-regulates TRH-R mRNA and present evidence that this action is mediated by protein kinase A. In GH3 cells, VIP caused a time- and concentration-dependent decrease in TRH-R mRNA. This VIP effect was simulated by 8-(4-chlorophenylthio)-cAMP, forskolin, cholera toxin and 1-methyl-3-isobutylxanthine. When cells were incubated with agents that elevate cAMP and TRH or phorbol 12-myristate 13-acetate, the decrease in TRH-R mRNA was greater than with either agent alone. When cells were pre-incubated with H-7 [1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride], an inhibitor of protein kinases, the effects of VIP, TRH and phorbol 12-myristate 13-acetate were inhibited. We suggest that VIP, via protein kinase A, and TRH, via protein kinase C, dually regulate TRH-R mRNA." @default.
- W2105203462 created "2016-06-24" @default.
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- W2105203462 date "1991-12-01" @default.
- W2105203462 modified "2023-09-26" @default.
- W2105203462 title "Evidence for Dual Regulation by Protein Kinases A and C of Thyrotropin-releasing Hormone Receptor mRNA in GH3Cells." @default.
- W2105203462 doi "https://doi.org/10.1210/endo-129-6-3430" @default.
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