Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105211149> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2105211149 endingPage "212" @default.
- W2105211149 startingPage "207" @default.
- W2105211149 abstract "The author considers studies with multiple dependent primary endpoints. Testing hypotheses with multiple primary endpoints may require unmanageably large populations. Composite endpoints consisting of several binary events may be used to reduce a trial to a manageable size. The primary difficulties with composite endpoints are that different endpoints may have different clinical importance and that higher-frequency variables may overwhelm effects of smaller, but equally important, primary outcomes. To compensate for these inconsistencies, we weight each type of event, and the total number of weighted events is counted. To reflect the mutual dependency of primary endpoints and to make the weighting method effective in small clinical trials, we use the Bayesian approach. We assume a multinomial distribution of multiple endpoints with Dirichlet priors and apply the Bayesian test of noninferiority to the calculation of weighting parameters. We use composite endpoints to test hypotheses of superiority in single-arm and two-arm clinical trials. The composite endpoints have a beta distribution. We illustrate this technique with an example. The results provide a statistical procedure for creating composite endpoints. Published 2013. This article is a U.S. Government work and is in the public domain in the USA." @default.
- W2105211149 created "2016-06-24" @default.
- W2105211149 creator A5046929498 @default.
- W2105211149 date "2013-04-29" @default.
- W2105211149 modified "2023-09-25" @default.
- W2105211149 title "Bayesian design and analysis of composite endpoints in clinical trials with multiple dependent binary outcomes" @default.
- W2105211149 cites W1429523837 @default.
- W2105211149 cites W1974737297 @default.
- W2105211149 cites W2009910175 @default.
- W2105211149 cites W2016819629 @default.
- W2105211149 cites W2018323223 @default.
- W2105211149 cites W2028170711 @default.
- W2105211149 cites W2031688249 @default.
- W2105211149 cites W2035882325 @default.
- W2105211149 cites W2042805913 @default.
- W2105211149 cites W2066366201 @default.
- W2105211149 cites W2069429561 @default.
- W2105211149 cites W2072564194 @default.
- W2105211149 cites W2086077933 @default.
- W2105211149 cites W2120368275 @default.
- W2105211149 cites W2160784493 @default.
- W2105211149 cites W2480935928 @default.
- W2105211149 doi "https://doi.org/10.1002/pst.1572" @default.
- W2105211149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23625660" @default.
- W2105211149 hasPublicationYear "2013" @default.
- W2105211149 type Work @default.
- W2105211149 sameAs 2105211149 @default.
- W2105211149 citedByCount "2" @default.
- W2105211149 countsByYear W21052111492015 @default.
- W2105211149 countsByYear W21052111492016 @default.
- W2105211149 crossrefType "journal-article" @default.
- W2105211149 hasAuthorship W2105211149A5046929498 @default.
- W2105211149 hasConcept C105795698 @default.
- W2105211149 hasConcept C107673813 @default.
- W2105211149 hasConcept C126322002 @default.
- W2105211149 hasConcept C126838900 @default.
- W2105211149 hasConcept C134306372 @default.
- W2105211149 hasConcept C149782125 @default.
- W2105211149 hasConcept C169214877 @default.
- W2105211149 hasConcept C177769412 @default.
- W2105211149 hasConcept C182310444 @default.
- W2105211149 hasConcept C183115368 @default.
- W2105211149 hasConcept C192065140 @default.
- W2105211149 hasConcept C203092338 @default.
- W2105211149 hasConcept C33923547 @default.
- W2105211149 hasConcept C41008148 @default.
- W2105211149 hasConcept C535046627 @default.
- W2105211149 hasConcept C71924100 @default.
- W2105211149 hasConceptScore W2105211149C105795698 @default.
- W2105211149 hasConceptScore W2105211149C107673813 @default.
- W2105211149 hasConceptScore W2105211149C126322002 @default.
- W2105211149 hasConceptScore W2105211149C126838900 @default.
- W2105211149 hasConceptScore W2105211149C134306372 @default.
- W2105211149 hasConceptScore W2105211149C149782125 @default.
- W2105211149 hasConceptScore W2105211149C169214877 @default.
- W2105211149 hasConceptScore W2105211149C177769412 @default.
- W2105211149 hasConceptScore W2105211149C182310444 @default.
- W2105211149 hasConceptScore W2105211149C183115368 @default.
- W2105211149 hasConceptScore W2105211149C192065140 @default.
- W2105211149 hasConceptScore W2105211149C203092338 @default.
- W2105211149 hasConceptScore W2105211149C33923547 @default.
- W2105211149 hasConceptScore W2105211149C41008148 @default.
- W2105211149 hasConceptScore W2105211149C535046627 @default.
- W2105211149 hasConceptScore W2105211149C71924100 @default.
- W2105211149 hasIssue "4" @default.
- W2105211149 hasLocation W21052111491 @default.
- W2105211149 hasLocation W21052111492 @default.
- W2105211149 hasOpenAccess W2105211149 @default.
- W2105211149 hasPrimaryLocation W21052111491 @default.
- W2105211149 hasRelatedWork W2011323311 @default.
- W2105211149 hasRelatedWork W2021634309 @default.
- W2105211149 hasRelatedWork W2044200030 @default.
- W2105211149 hasRelatedWork W2053369617 @default.
- W2105211149 hasRelatedWork W2059984851 @default.
- W2105211149 hasRelatedWork W2169111089 @default.
- W2105211149 hasRelatedWork W2234983025 @default.
- W2105211149 hasRelatedWork W2373836695 @default.
- W2105211149 hasRelatedWork W3171116345 @default.
- W2105211149 hasRelatedWork W573118773 @default.
- W2105211149 hasVolume "12" @default.
- W2105211149 isParatext "false" @default.
- W2105211149 isRetracted "false" @default.
- W2105211149 magId "2105211149" @default.
- W2105211149 workType "article" @default.