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- W2105220254 abstract "Colorectal cancer is one of the most prevalent cancers in developed countries. However, the genetic factors influencing its appearance remain far from being fully characterized. Recently, a G>A functional transition mapping the 3' untranslated region of the CXCL12 gene (rs1801157) has been found to be under-represented among rectal cancer patients when compared to colon cancer patients from a Swedish series. Here we present the results from an independent analysis of CXCL12 rs1801157 in a larger CRC series of Spanish origin in order to analyse the robustness of this association within a different European population. No significant difference was observed between controls and colon or rectal cancer patients. We were also unable to find a correlation between rs1801157 and different prognostic markers such as metastasis development or disease-free survival time. The epidemiologic data involving CXCL12 rs1801157 in colorectal cancer risk are discussed." @default.
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- W2105220254 date "2007-12-01" @default.
- W2105220254 modified "2023-10-18" @default.
- W2105220254 title "Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer" @default.
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- W2105220254 doi "https://doi.org/10.3892/or.18.6.1583" @default.
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