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• W2105220777 abstract "There is growing evidence that the effects of microcystin-LR (MC-LR) are closely related to apoptosis. This study utilized microarray to identify the apoptosis-related genes induced by MC-LR in zebrafish liver. The messenger RNA abundance of some apoptosis-related genes was found to be increased, including five tumor necrosis factor (TNF)-related members (apoptosis regulatory protein siva, tumor necrosis factor–α ( tnfa) TNF (ligand) superfamily member 10 ( tnfsf10), TNF-inducible protein 6 ( tnfaip6) and TNF receptor associated factor 2 binding protein ( traf2bp)), three p53-related genes (tumor protein p53 inducible nuclear protein 1 ( tp53inp1), p53-induced protein phosphatase 1 ( ppm1d) and a novel apoptosis stimulating protein of p53 ( aspp2)), bcl 2 family members (proapoptosis gene bax and antiapoptosis gene mcl 1), caspases (caspase y ( caspy) and a PYD and CARD domain-containing protein ( pycard)) and the transforming growth factor beta (TGF-β) induced apoptosis protein 2 ( taip2). Real-time polymerase chain reaction was used to study the kinetic transcriptional changes in seven apoptosis-related genes. Elevated transcription of p53, tp53inp1, mcl 1 and taip2 could only be detected at 6 h, increased transcription of the antagonist molecules, bcl 2 and bax could be detected at most time points and the significant change of caspy could be found at 48 h and 72 h after stimulation. Taken together, the results obtained in the present study clearly demonstrate that large amount of apoptosis-related genes are involved in the regulation of MC-LR-induced apoptosis." @default.
• W2105220777 created "2016-06-24" @default.
• W2105220777 creator A5020043551 @default.
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• W2105220777 date "2012-10-11" @default.
• W2105220777 modified "2023-09-24" @default.
• W2105220777 title "Identification of apoptosis-related genes and transcription variations in response to microcystin-LR in zebrafish liver" @default.
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• W2105220777 doi "https://doi.org/10.1177/0748233712462443" @default.
• W2105220777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23064767" @default.
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