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• W2105225614 abstract "Background No published meta-analyses have assessed efficacy and effectiveness of licensed influenza vaccines in the USA with sensitive and highly specific diagnostic tests to confirm influenza. Methods We searched Medline for randomised controlled trials assessing a relative reduction in influenza risk of all circulating influenza viruses during individual seasons after vaccination (efficacy) and observational studies meeting inclusion criteria (effectiveness). Eligible articles were published between Jan 1, 1967, and Feb 15, 2011, and used RT-PCR or culture for confirmation of influenza. We excluded some studies on the basis of study design and vaccine characteristics. We estimated random-effects pooled efficacy for trivalent inactivated vaccine (TIV) and live attenuated influenza vaccine (LAIV) when data were available for statistical analysis (eg, at least three studies that assessed comparable age groups). Findings We screened 5707 articles and identified 31 eligible studies (17 randomised controlled trials and 14 observational studies). Efficacy of TIV was shown in eight (67%) of the 12 seasons analysed in ten randomised controlled trials (pooled efficacy 59% [95% CI 51–67] in adults aged 18–65 years). No such trials met inclusion criteria for children aged 2–17 years or adults aged 65 years or older. Efficacy of LAIV was shown in nine (75%) of the 12 seasons analysed in ten randomised controlled trials (pooled efficacy 83% [69–91]) in children aged 6 months to 7 years. No such trials met inclusion criteria for children aged 8–17 years. Vaccine effectiveness was variable for seasonal influenza: six (35%) of 17 analyses in nine studies showed significant protection against medically attended influenza in the outpatient or inpatient setting. Median monovalent pandemic H1N1 vaccine effectiveness in five observational studies was 69% (range 60–93). Interpretation Influenza vaccines can provide moderate protection against virologically confirmed influenza, but such protection is greatly reduced or absent in some seasons. Evidence for protection in adults aged 65 years or older is lacking. LAIVs consistently show highest efficacy in young children (aged 6 months to 7 years). New vaccines with improved clinical efficacy and effectiveness are needed to further reduce influenza-related morbidity and mortality. Funding Alfred P Sloan Foundation. No published meta-analyses have assessed efficacy and effectiveness of licensed influenza vaccines in the USA with sensitive and highly specific diagnostic tests to confirm influenza. We searched Medline for randomised controlled trials assessing a relative reduction in influenza risk of all circulating influenza viruses during individual seasons after vaccination (efficacy) and observational studies meeting inclusion criteria (effectiveness). Eligible articles were published between Jan 1, 1967, and Feb 15, 2011, and used RT-PCR or culture for confirmation of influenza. We excluded some studies on the basis of study design and vaccine characteristics. We estimated random-effects pooled efficacy for trivalent inactivated vaccine (TIV) and live attenuated influenza vaccine (LAIV) when data were available for statistical analysis (eg, at least three studies that assessed comparable age groups). We screened 5707 articles and identified 31 eligible studies (17 randomised controlled trials and 14 observational studies). Efficacy of TIV was shown in eight (67%) of the 12 seasons analysed in ten randomised controlled trials (pooled efficacy 59% [95% CI 51–67] in adults aged 18–65 years). No such trials met inclusion criteria for children aged 2–17 years or adults aged 65 years or older. Efficacy of LAIV was shown in nine (75%) of the 12 seasons analysed in ten randomised controlled trials (pooled efficacy 83% [69–91]) in children aged 6 months to 7 years. No such trials met inclusion criteria for children aged 8–17 years. Vaccine effectiveness was variable for seasonal influenza: six (35%) of 17 analyses in nine studies showed significant protection against medically attended influenza in the outpatient or inpatient setting. Median monovalent pandemic H1N1 vaccine effectiveness in five observational studies was 69% (range 60–93). Influenza vaccines can provide moderate protection against virologically confirmed influenza, but such protection is greatly reduced or absent in some seasons. Evidence for protection in adults aged 65 years or older is lacking. LAIVs consistently show highest efficacy in young children (aged 6 months to 7 years). New vaccines with improved clinical efficacy and effectiveness are needed to further reduce influenza-related morbidity and mortality." @default.
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• W2105225614 date "2012-01-01" @default.
• W2105225614 modified "2023-10-11" @default.
• W2105225614 title "Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis" @default.
• W2105225614 cites W1967114815 @default.
• W2105225614 cites W1982310373 @default.
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• W2105225614 cites W1987885018 @default.
• W2105225614 cites W1987973326 @default.
• W2105225614 cites W2010820891 @default.
• W2105225614 cites W2015327835 @default.
• W2105225614 cites W2016272753 @default.
• W2105225614 cites W2027478882 @default.
• W2105225614 cites W2031809616 @default.
• W2105225614 cites W2034712058 @default.
• W2105225614 cites W2044674855 @default.
• W2105225614 cites W2054383700 @default.
• W2105225614 cites W2055443001 @default.
• W2105225614 cites W2060873578 @default.
• W2105225614 cites W2063554346 @default.
• W2105225614 cites W2075919195 @default.
• W2105225614 cites W2078434876 @default.
• W2105225614 cites W2083450984 @default.
• W2105225614 cites W2085724483 @default.
• W2105225614 cites W2088010072 @default.
• W2105225614 cites W2091080683 @default.
• W2105225614 cites W2091813869 @default.
• W2105225614 cites W2096446411 @default.
• W2105225614 cites W2097034992 @default.
• W2105225614 cites W2102234370 @default.
• W2105225614 cites W2103274547 @default.
• W2105225614 cites W2105027546 @default.
• W2105225614 cites W2107739935 @default.
• W2105225614 cites W2110962836 @default.
• W2105225614 cites W2111693224 @default.
• W2105225614 cites W2114486596 @default.
• W2105225614 cites W2116090359 @default.
• W2105225614 cites W2120718343 @default.
• W2105225614 cites W2122922626 @default.
• W2105225614 cites W2124506472 @default.
• W2105225614 cites W2124750800 @default.
• W2105225614 cites W2133319531 @default.
• W2105225614 cites W2135024030 @default.
• W2105225614 cites W2136603923 @default.
• W2105225614 cites W2138845246 @default.
• W2105225614 cites W2140360974 @default.
• W2105225614 cites W2140415886 @default.
• W2105225614 cites W2141118973 @default.
• W2105225614 cites W2141330138 @default.
• W2105225614 cites W2148357338 @default.
• W2105225614 cites W2149698567 @default.
• W2105225614 cites W2164621648 @default.
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• W2105225614 cites W2168552128 @default.
• W2105225614 cites W2169229646 @default.
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• W2105225614 cites W2336491233 @default.
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• W2105225614 doi "https://doi.org/10.1016/s1473-3099(11)70295-x" @default.
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