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• W2105226875 abstract "Previous cross-sectional studies have observed alterations in activity rhythms in patients with dementia but the direction of causation is unclear. We determined whether circadian activity rhythms measured in community-dwelling older women are prospectively associated with risk of incident dementia or mild cognitive impairment (MCI). A prospective cohort study of healthy older women (mean age 83 years) from three US clinic sites was performed among 1,282 community-dwelling women from the Study of Osteoporotic Fractures cohort. Circadian activity rhythm data were collected in 2002-2004 with wrist actigraphy for a minimum of three 24-hour periods. Parameters of interest included time of peak activity (acrophase), height of activity peak (amplitude), mean activity level (mesor), and strength of activity rhythm (robustness). Each participant also completed a neuropsychological test battery and had clinical cognitive status (dementia, MCI or normal) adjudicated by an expert panel approximately 5 years later. All analyses were adjusted for demographics, BMI, exercise, functional status, depression, medications, alcohol, caffeine, smoking, self-reported health status, and co-morbidities. After 4.9 years of follow-up, 195 (15%) women had developed dementia and 302 (24%) had developed MCI. When compared to women with average timing of peak activity (1:34PM-3:51PM), those whose timing of peak activity occurred later in the day (after 3:51PM) had an increased risk of developing dementia (Odds Ratio [OR] = 1.67, 95% Confidence Intervals [CI], 1.07-2.61) or MCI (OR = 1.73, 95% CI, 1.15-2.61). Compared with women in the highest quartiles of amplitude or rhythm robustness, those in the lowest quartiles had a higher likelihood of developing dementia or MCI (Amplitude, OR = 1.54, 95% CI, 1.07-2.21; robustness OR = 1.55, 95% CI, 1.08-2.22). Among older women without cognitive impairment at baseline, those with weak and late-shifted circadian activity rhythms have increased odds of developing dementia and MCI. If confirmed in other prospective cohorts, studies will be needed to test whether interventions (e.g. physical activity, bright light exposure) that influence circadian activity rhythms will reduce the risk of cognitive decline in the elderly." @default.
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• W2105226875 date "2011-07-01" @default.
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• W2105226875 title "P2-188: Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women" @default.
• W2105226875 doi "https://doi.org/10.1016/j.jalz.2011.05.1074" @default.
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