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• W2105232382 abstract "Gene duplications are one of the primary driving forces in the evolution of genomes and genetic systems. Gene duplicates account for 8–20% of the genes in eukaryotic genomes, and the rates of gene duplication are estimated at between 0.2% and 2% per gene per million years. Duplicate genes are believed to be a major mechanism for the establishment of new gene functions and the generation of evolutionary novelty, yet very little is known about the early stages of the evolution of duplicated gene pairs. It is unclear, for example, to what extent selection, rather than neutral genetic drift, drives the fixation and early evolution of duplicate loci. Analysis of recently duplicated genes in the Arabidopsis thaliana genome reveals significantly reduced species-wide levels of nucleotide polymorphisms in the progenitor and/or duplicate gene copies, suggesting that selective sweeps accompany the initial stages of the evolution of these duplicated gene pairs. Our results support recent theoretical work that indicates that fates of duplicate gene pairs may be determined in the initial phases of duplicate gene evolution and that positive selection plays a prominent role in the evolutionary dynamics of the very early histories of duplicate nuclear genes." @default.
• W2105232382 created "2016-06-24" @default.
• W2105232382 creator A5036110581 @default.
• W2105232382 creator A5056278105 @default.
• W2105232382 date "2003-12-11" @default.
• W2105232382 modified "2023-10-13" @default.
• W2105232382 title "The early stages of duplicate gene evolution" @default.
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• W2105232382 doi "https://doi.org/10.1073/pnas.2535513100" @default.
• W2105232382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/307628" @default.
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