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• W2105240882 abstract "During infection by herpes simplex virus type 1 (HSV-1), the virion protein VP16 activates the transcription of viral immediate-early (IE) genes. Genetic and biochemical assays have shown that the potent transcriptional activation domain of VP16 can associate with general transcription factors and with chromatin-modifying coactivator proteins of several types. The latter interactions are particularly intriguing because previous reports indicate that HSV-1 DNA does not become nucleosomal during lytic infection. In the present work, chemical cross-linking and immunoprecipitation assays were used to probe the presence of activators, general transcription factors, and chromatin-modifying coactivators at IE gene promoters during infection of HeLa cells by wild-type HSV-1 and by RP5, a viral strain lacking the VP16 transcriptional activation domain. The presence of VP16 and Oct-1 at IE promoters did not depend on the activation domain. In contrast, association of RNA polymerase II, TATA-binding protein, histone acetyltransferases (p300 and CBP), and ATP-dependent remodeling proteins (BRG1 and hBRM) with IE gene promoters was observed in wild-type infections but was absent or reduced in cells infected by RP5. In contrast to the previous evidence for nonnucleosomal HSV-1 DNA, histone H3 was found associated with viral DNA at early times of infection. Interestingly, histone H3 was underrepresented on IE promoters in a manner dependent on the VP16 activation domain. Thus, the VP16 activation domain is responsible for recruiting general transcription factors and coactivators to IE promoters and also for dramatically reducing the association of histones with those promoters." @default.
• W2105240882 created "2016-06-24" @default.
• W2105240882 creator A5045016749 @default.
• W2105240882 creator A5087578365 @default.
• W2105240882 date "2004-09-15" @default.
• W2105240882 modified "2023-10-13" @default.
• W2105240882 title "VP16-Dependent Association of Chromatin-Modifying Coactivators and Underrepresentation of Histones at Immediate-Early Gene Promoters during Herpes Simplex Virus Infection" @default.
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• W2105240882 doi "https://doi.org/10.1128/jvi.78.18.9689-9696.2004" @default.
• W2105240882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/515004" @default.
• W2105240882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15331701" @default.
• W2105240882 hasPublicationYear "2004" @default.
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