Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105252014> ?p ?o ?g. }
- W2105252014 endingPage "642" @default.
- W2105252014 startingPage "637" @default.
- W2105252014 abstract "Reported habits of red meat consumption, particularly red meat that has been cooked to the degree termed ‘well-done’, is a positive risk factor for colorectal cancer. Under high, pyrolytic temperatures, heterocyclic amines (HCA) and benzo[ a ]pyrene (BP) molecules can form inside and on the surface of red meat, respectively. These compounds are precursors that are metabolically converted to compounds known to act as mutagens and carcinogens in animal models, yet their role in human colorectal carcinogenesis remains to be clarified. We investigated whether intake of these compounds is associated with risk of colorectal adenoma in the context of a polyp-screening study conducted in Southern California. Using a database of individual HCAs and BP in meats of various types and subjected to specified methods and degrees of cooking, we estimated nanogram consumption of 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine, 2-amino-3,4,8-trimethylimidazo[4,5- f ] quinoxaline, 2-amino-3,8-dimethylimidazo[4,5- f ]quinoxaline and benzo[ a ]pyrene (BP). We observed a 6% increased risk of large (>1 cm) adenoma per 10 ng/day consumption of BP [OR = 1.06 (95% CI, 1.00–1.12), P (trend) = 0.04]. A major source of BP is red meat exposed to a naked flame, as occurs during the barbecuing process. Consistent with this finding an incremental increase of 10 g of barbecued red meat per day was associated with a 29% increased risk of large adenoma [OR = 1.29 (95% CI, 1.02–1.63), P (trend) = 0.04]. Individuals in the top quintile of barbecued red meat intake were at increased risk of large adenoma [OR = 1.90 (95% CI, 1.04–3.45)], compared with never consuming barbecued red meat. The consumption of oven-broiled red meat was inversely related to adenoma risk compared with non-consumers [OR = 0.49 (95% CI, 0.28–0.85)]. We did not identify any association with consumption of individual HCAs and colorectal adenoma risk. These results support the hypothesis that BP contributes to colorectal carcinogenesis." @default.
- W2105252014 created "2016-06-24" @default.
- W2105252014 creator A5007262202 @default.
- W2105252014 creator A5023377639 @default.
- W2105252014 creator A5026418441 @default.
- W2105252014 creator A5046773247 @default.
- W2105252014 creator A5074815814 @default.
- W2105252014 creator A5084125220 @default.
- W2105252014 date "2004-09-09" @default.
- W2105252014 modified "2023-09-23" @default.
- W2105252014 title "Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control study" @default.
- W2105252014 cites W1481057965 @default.
- W2105252014 cites W1881840670 @default.
- W2105252014 cites W2012062618 @default.
- W2105252014 cites W2041374450 @default.
- W2105252014 cites W2046219406 @default.
- W2105252014 cites W2062411459 @default.
- W2105252014 cites W2072509437 @default.
- W2105252014 cites W2081012263 @default.
- W2105252014 cites W2083293033 @default.
- W2105252014 cites W2116561567 @default.
- W2105252014 cites W2120877678 @default.
- W2105252014 cites W2124318306 @default.
- W2105252014 cites W2135224573 @default.
- W2105252014 cites W2143366617 @default.
- W2105252014 cites W2144988754 @default.
- W2105252014 cites W2148595234 @default.
- W2105252014 cites W2158946056 @default.
- W2105252014 cites W2163656748 @default.
- W2105252014 cites W2164121632 @default.
- W2105252014 cites W2166577367 @default.
- W2105252014 cites W232917471 @default.
- W2105252014 cites W2438638163 @default.
- W2105252014 doi "https://doi.org/10.1093/carcin/bgh350" @default.
- W2105252014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15579480" @default.
- W2105252014 hasPublicationYear "2004" @default.
- W2105252014 type Work @default.
- W2105252014 sameAs 2105252014 @default.
- W2105252014 citedByCount "90" @default.
- W2105252014 countsByYear W21052520142012 @default.
- W2105252014 countsByYear W21052520142013 @default.
- W2105252014 countsByYear W21052520142014 @default.
- W2105252014 countsByYear W21052520142015 @default.
- W2105252014 countsByYear W21052520142016 @default.
- W2105252014 countsByYear W21052520142017 @default.
- W2105252014 countsByYear W21052520142018 @default.
- W2105252014 countsByYear W21052520142019 @default.
- W2105252014 countsByYear W21052520142020 @default.
- W2105252014 countsByYear W21052520142021 @default.
- W2105252014 countsByYear W21052520142022 @default.
- W2105252014 countsByYear W21052520142023 @default.
- W2105252014 crossrefType "journal-article" @default.
- W2105252014 hasAuthorship W2105252014A5007262202 @default.
- W2105252014 hasAuthorship W2105252014A5023377639 @default.
- W2105252014 hasAuthorship W2105252014A5026418441 @default.
- W2105252014 hasAuthorship W2105252014A5046773247 @default.
- W2105252014 hasAuthorship W2105252014A5074815814 @default.
- W2105252014 hasAuthorship W2105252014A5084125220 @default.
- W2105252014 hasBestOaLocation W21052520141 @default.
- W2105252014 hasConcept C114246631 @default.
- W2105252014 hasConcept C121608353 @default.
- W2105252014 hasConcept C126322002 @default.
- W2105252014 hasConcept C151730666 @default.
- W2105252014 hasConcept C185592680 @default.
- W2105252014 hasConcept C2776861080 @default.
- W2105252014 hasConcept C2777428134 @default.
- W2105252014 hasConcept C2778089274 @default.
- W2105252014 hasConcept C2779343474 @default.
- W2105252014 hasConcept C31903555 @default.
- W2105252014 hasConcept C50440223 @default.
- W2105252014 hasConcept C526805850 @default.
- W2105252014 hasConcept C55493867 @default.
- W2105252014 hasConcept C71924100 @default.
- W2105252014 hasConcept C86803240 @default.
- W2105252014 hasConcept C90924648 @default.
- W2105252014 hasConceptScore W2105252014C114246631 @default.
- W2105252014 hasConceptScore W2105252014C121608353 @default.
- W2105252014 hasConceptScore W2105252014C126322002 @default.
- W2105252014 hasConceptScore W2105252014C151730666 @default.
- W2105252014 hasConceptScore W2105252014C185592680 @default.
- W2105252014 hasConceptScore W2105252014C2776861080 @default.
- W2105252014 hasConceptScore W2105252014C2777428134 @default.
- W2105252014 hasConceptScore W2105252014C2778089274 @default.
- W2105252014 hasConceptScore W2105252014C2779343474 @default.
- W2105252014 hasConceptScore W2105252014C31903555 @default.
- W2105252014 hasConceptScore W2105252014C50440223 @default.
- W2105252014 hasConceptScore W2105252014C526805850 @default.
- W2105252014 hasConceptScore W2105252014C55493867 @default.
- W2105252014 hasConceptScore W2105252014C71924100 @default.
- W2105252014 hasConceptScore W2105252014C86803240 @default.
- W2105252014 hasConceptScore W2105252014C90924648 @default.
- W2105252014 hasIssue "3" @default.
- W2105252014 hasLocation W21052520141 @default.
- W2105252014 hasLocation W21052520142 @default.
- W2105252014 hasLocation W21052520143 @default.
- W2105252014 hasLocation W21052520144 @default.
- W2105252014 hasLocation W21052520145 @default.
- W2105252014 hasOpenAccess W2105252014 @default.