FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105258846> ?p ?o ?g. }

• W2105258846 endingPage "3446" @default.
• W2105258846 startingPage "3434" @default.
• W2105258846 abstract "Cell coupling is important for the normal function of the beta-cells of the pancreatic islet of Langerhans, which secrete insulin in response to elevated plasma glucose. In the islets, electrical and metabolic communications are mediated by gap junctions. Although electrical coupling is believed to account for synchronization of the islets, the role and significance of diffusion of calcium and metabolites are not clear. To address these questions we analyze two different mathematical models of islet calcium and electrical dynamics. To study diffusion of calcium, we use a modified Morris-Lecar model. Based on our analysis, we conclude that intercellular diffusion of calcium is not necessary for islet synchronization, at most supplementing electrical coupling. Metabolic coupling is investigated with a recent mathematical model incorporating glycolytic oscillations. Bifurcation analysis of the coupled system reveals several modes of behavior, depending on the relative strength of electrical and metabolic coupling. We find that whereas electrical coupling always produces synchrony, metabolic coupling can abolish both oscillations and synchrony, explaining some puzzling experimental observations. We suggest that these modes are generic features of square-wave bursters and relaxation oscillators coupled through either the activation or recovery variable." @default.
• W2105258846 created "2016-06-24" @default.
• W2105258846 creator A5013857769 @default.
• W2105258846 creator A5032939455 @default.
• W2105258846 creator A5033339412 @default.
• W2105258846 creator A5035615115 @default.
• W2105258846 date "2006-05-01" @default.
• W2105258846 modified "2023-10-15" @default.
• W2105258846 title "Diffusion of Calcium and Metabolites in Pancreatic Islets: Killing Oscillations with a Pitchfork" @default.
• W2105258846 cites W1643127595 @default.
• W2105258846 cites W1963799745 @default.
• W2105258846 cites W1965580291 @default.
• W2105258846 cites W1972048798 @default.
• W2105258846 cites W1975347125 @default.
• W2105258846 cites W1978976435 @default.
• W2105258846 cites W1990044372 @default.
• W2105258846 cites W1992462569 @default.
• W2105258846 cites W2006617024 @default.
• W2105258846 cites W2015823678 @default.
• W2105258846 cites W2018584626 @default.
• W2105258846 cites W2022870633 @default.
• W2105258846 cites W2027267866 @default.
• W2105258846 cites W2030689510 @default.
• W2105258846 cites W2031643955 @default.
• W2105258846 cites W2040749189 @default.
• W2105258846 cites W2042630355 @default.
• W2105258846 cites W2045762972 @default.
• W2105258846 cites W2046424015 @default.
• W2105258846 cites W2059794538 @default.
• W2105258846 cites W2063349025 @default.
• W2105258846 cites W2064528021 @default.
• W2105258846 cites W2067019552 @default.
• W2105258846 cites W2067542515 @default.
• W2105258846 cites W2069035576 @default.
• W2105258846 cites W2077409251 @default.
• W2105258846 cites W2080940048 @default.
• W2105258846 cites W2091609447 @default.
• W2105258846 cites W2094657730 @default.
• W2105258846 cites W2108896758 @default.
• W2105258846 cites W2112043438 @default.
• W2105258846 cites W2121760611 @default.
• W2105258846 cites W2122464404 @default.
• W2105258846 cites W2127153289 @default.
• W2105258846 cites W2128748529 @default.
• W2105258846 cites W2135749721 @default.
• W2105258846 cites W2139132103 @default.
• W2105258846 cites W2144287511 @default.
• W2105258846 cites W2145625706 @default.
• W2105258846 cites W2151444325 @default.
• W2105258846 cites W2155181139 @default.
• W2105258846 cites W2162919223 @default.
• W2105258846 cites W2167254595 @default.
• W2105258846 cites W2318527153 @default.
• W2105258846 doi "https://doi.org/10.1529/biophysj.105.078360" @default.
• W2105258846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1440728" @default.
• W2105258846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16500973" @default.
• W2105258846 hasPublicationYear "2006" @default.
• W2105258846 type Work @default.
• W2105258846 sameAs 2105258846 @default.
• W2105258846 citedByCount "82" @default.
• W2105258846 countsByYear W21052588462012 @default.
• W2105258846 countsByYear W21052588462013 @default.
• W2105258846 countsByYear W21052588462014 @default.
• W2105258846 countsByYear W21052588462015 @default.
• W2105258846 countsByYear W21052588462016 @default.
• W2105258846 countsByYear W21052588462017 @default.
• W2105258846 countsByYear W21052588462018 @default.
• W2105258846 countsByYear W21052588462019 @default.
• W2105258846 countsByYear W21052588462020 @default.
• W2105258846 countsByYear W21052588462021 @default.
• W2105258846 countsByYear W21052588462022 @default.
• W2105258846 countsByYear W21052588462023 @default.
• W2105258846 crossrefType "journal-article" @default.
• W2105258846 hasAuthorship W2105258846A5013857769 @default.
• W2105258846 hasAuthorship W2105258846A5032939455 @default.
• W2105258846 hasAuthorship W2105258846A5033339412 @default.
• W2105258846 hasAuthorship W2105258846A5035615115 @default.
• W2105258846 hasBestOaLocation W21052588461 @default.
• W2105258846 hasConcept C121332964 @default.
• W2105258846 hasConcept C12554922 @default.
• W2105258846 hasConcept C131584629 @default.
• W2105258846 hasConcept C134018914 @default.
• W2105258846 hasConcept C158157758 @default.
• W2105258846 hasConcept C165220095 @default.
• W2105258846 hasConcept C178790620 @default.
• W2105258846 hasConcept C181080969 @default.
• W2105258846 hasConcept C185592680 @default.
• W2105258846 hasConcept C191897082 @default.
• W2105258846 hasConcept C192562407 @default.
• W2105258846 hasConcept C2779306644 @default.
• W2105258846 hasConcept C2779855799 @default.
• W2105258846 hasConcept C519063684 @default.
• W2105258846 hasConcept C55493867 @default.
• W2105258846 hasConcept C69357855 @default.
• W2105258846 hasConcept C79879829 @default.
• W2105258846 hasConcept C86803240 @default.
• W2105258846 hasConcept C97355855 @default.
• W2105258846 hasConceptScore W2105258846C121332964 @default.

• next