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• W2105266148 abstract "We have previously shown that ML-7, which inhibits myosin light chain kinase (MLCK), induces apoptosis in transformed and non-transformed cells. We have extended these studies and found that ML-7 stimulates the ability of etoposide to induce apoptosis in Mm5MT mouse mammary adenocarcinoma cells and Mat-Ly-Lu rat prostate cancer cells in vitro. ML-7 was also found to have a chemopreventive effect using an in vitro mouse mammary organ culture model. In vivo experiments demonstrated that ML-7 retards the growth of mammary tumours in mice and prostate tumours in rats. Moreover, ML-7 significantly stimulates the ability of etoposide to prevent the growth of established mammary tumours in mice and prostate tumours in rats. These results provide evidence for the efficacy of ML-7 as an adjuvant to etoposide in these models and warrants further development." @default.
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• W2105266148 date "2006-05-01" @default.
• W2105266148 modified "2023-10-16" @default.
• W2105266148 title "Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells" @default.
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• W2105266148 doi "https://doi.org/10.1016/j.ejca.2005.12.017" @default.
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