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• W2105280248 abstract "For several decades, it has been known that mental retardation (MR) is associated with abnormalities in dendrites and dendritic spines. The recent cloning of seven genes that cause nonspecific MR when mutated provides important insights in the cellular mechanisms that result in the dendritic abnormalities associated with MR. Three of the encoded proteins, oligophrenin 1, PAK3 and alpha PIX, interact directly with Rho GTPases. Rho GTPases are key signaling proteins that integrate extracellular and intracellular signals to orchestrate coordinated changes in the actin cytoskeleton essential for directed neurite outgrowth and the regulation of synaptic connectivity. Although many details of the cell biology of Rho signaling in the CNS are still unclear, a picture is unfolding showing how mutations that alter Rho signaling result in abnormal neuronal connectivity and deficient cognitive functioning in humans. Conversely, these findings illuminate the cellular mechanisms underlying normal cognitive function." @default.
• W2105280248 created "2016-06-24" @default.
• W2105280248 creator A5045529956 @default.
• W2105280248 date "2002-04-01" @default.
• W2105280248 modified "2023-10-02" @default.
• W2105280248 title "Rho proteins, mental retardation and the cellular basis of cognition" @default.
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• W2105280248 doi "https://doi.org/10.1016/s0166-2236(00)02118-4" @default.
• W2105280248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11998687" @default.
• W2105280248 hasPublicationYear "2002" @default.
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