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- W2105280277 abstract "Abstract The present study demonstrates that the secretion of azurophilic granules occurring during Fc receptor-mediated attachment and spreading of neutrophils is highly localized to the adhering region of the cell. In contrast, the secretion of specific granules occurs in a nonpolarized way. This implies that unique signals are involved in the regulation of azurophilic degranulation. Assembly of actin filaments, as visualized by staining with rhodamine phalloidin, neither hindered nor facilitated degranulation. Further, the azurophilic secretory response remained localized in the presence of cytochalasin B. Release of azurophilic-granule content was inhibited by genistein and erbstatin, inhibitors of tyrosine kinases, and by GF109203X, a protein kinase C (PKC) inhibitor. We could also demonstrate a relative enrichment of syk tyrosine kinase and the PKC isoforms α and β1 in adherent plasma membranes." @default.
- W2105280277 created "2016-06-24" @default.
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- W2105280277 date "2002-04-01" @default.
- W2105280277 modified "2023-10-17" @default.
- W2105280277 title "Signaling to localized degranulation in neutrophils adherent to immune complexes" @default.
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- W2105280277 doi "https://doi.org/10.1189/jlb.71.4.701" @default.
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