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- W2105280578 abstract "Abstract Aim : To identify factors related to indomethacin non‐responsiveness for patent ductus arteriosus (PDA) closure in very‐low‐birthweight (VLBW) neonates. Methods : A chart review of 107 VLBW neonates with a clinical diagnosis of PDA who received indomethacin, admitted to a tertiary neonatal intensive care unit in Toronto, Canada, was conducted (study period November 2001 to October 2003). Positive responders were those with no clinical evidence of PDA for 72 h after indomethacin. Results : Response to the first course of indomethacin was 75%, and to the second course 67% among initial responders. Higher CRIB score (OR 1.15, 95% CI 1.02–1.31) and early surfactant administration (OR 3.74, 95% CI 1.04–13.47) were associated with non‐responsiveness to indomethacin. Conclusion : Indomethacin is effective for PDA closure. The response rate diminished with subsequent courses. Early surfactant and severity of illness at admission were associated with non‐responsiveness to indomethacin." @default.
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- W2105280578 date "2006-11-01" @default.
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- W2105280578 title "Effect of indomethacin on closure of ductus arteriosus in very-low-birthweight neonates1Presented at the Annual Meeting of the Canadian Paediatric Society, Montreal, Canada, 2004." @default.
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- W2105280578 doi "https://doi.org/10.1080/08035250600615150" @default.
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