FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105282783> ?p ?o ?g. }

• W2105282783 endingPage "1360" @default.
• W2105282783 startingPage "1357" @default.
• W2105282783 abstract "Curcumin (diferuloylmethane), the major yellow pigment in turmeric, has been shown to inhibit benzo[a]pyrene (BaP)-induced forestomach cancer in mice through mechanism(s) not fully understood. It is well known that while cytochrome P4501A1 (CYP1A1) and epoxide hydrolase (EH) are important in the conversion of BaP to its activated form, (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-anti-BaPDE], the detoxification of (+)-anti-BaPDE is accomplished by glutathione (GSH) S-transferases (GST). Therefore, it seems reasonable to postulate that curcumin may exert anti-carcinogenic activity either by inhibiting activation of BaP or (and) by enhancing the detoxification of (+)-anti-BaPDE. Administration p.o. of 2% curcumin in the diet to female A/J mice for 14 days, which has been shown to cause a significant inhibition in BaP-induced forestomach tumorigenesis, resulted in a modest but statistically significant reduction in hepatic ethoxyresorufin O-deethylase (EROD) activity, a reaction preferentially catalyzed by CYP1A1. While EROD activity could not be detected in the forestomach of either control or treated mice, curcumin feeding caused a statistically significant increase (approximately 2.3-fold) in hepatic EH and GST activities. Hepatic and forestomach GSH levels, and forestomach EH and GST activities were not affected by curcumin treatment. Even though the levels of various hepatic GST isoenzymes were significantly increased upon curcumin feeding, maximum induction was noticed for the pi class isoenzyme (mGSTP1-1), which among murine hepatic GSTs is highly efficient in the detoxification of (+)-anti-BaPDE. In conclusion, the results of the present study suggest that curcumin may inhibit BaP-induced forestomach cancer in mice by affecting both activation as well as inactivation pathways of BaP metabolism in the liver." @default.
• W2105282783 created "2016-06-24" @default.
• W2105282783 creator A5001753331 @default.
• W2105282783 creator A5002600242 @default.
• W2105282783 creator A5022942037 @default.
• W2105282783 creator A5029866856 @default.
• W2105282783 creator A5038489527 @default.
• W2105282783 creator A5041976342 @default.
• W2105282783 creator A5054511388 @default.
• W2105282783 date "1998-08-01" @default.
• W2105282783 modified "2023-10-16" @default.
• W2105282783 title "Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin" @default.
• W2105282783 cites W1178217335 @default.
• W2105282783 cites W1205902433 @default.
• W2105282783 cites W1501747388 @default.
• W2105282783 cites W1509148122 @default.
• W2105282783 cites W1581414347 @default.
• W2105282783 cites W172739833 @default.
• W2105282783 cites W1881840670 @default.
• W2105282783 cites W1902072415 @default.
• W2105282783 cites W1940692058 @default.
• W2105282783 cites W1964278933 @default.
• W2105282783 cites W1969486561 @default.
• W2105282783 cites W1981583871 @default.
• W2105282783 cites W1982082751 @default.
• W2105282783 cites W1984490307 @default.
• W2105282783 cites W1993557939 @default.
• W2105282783 cites W1999068029 @default.
• W2105282783 cites W2020641997 @default.
• W2105282783 cites W2033147111 @default.
• W2105282783 cites W2035308484 @default.
• W2105282783 cites W2037102375 @default.
• W2105282783 cites W2044936196 @default.
• W2105282783 cites W2046750894 @default.
• W2105282783 cites W2046946141 @default.
• W2105282783 cites W2064425376 @default.
• W2105282783 cites W2064845643 @default.
• W2105282783 cites W2090874882 @default.
• W2105282783 cites W2098562843 @default.
• W2105282783 cites W2128635872 @default.
• W2105282783 cites W21429993 @default.
• W2105282783 cites W2161288249 @default.
• W2105282783 cites W2169265798 @default.
• W2105282783 cites W2195375524 @default.
• W2105282783 cites W2266929960 @default.
• W2105282783 cites W2606440746 @default.
• W2105282783 doi "https://doi.org/10.1093/carcin/19.8.1357" @default.
• W2105282783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9744529" @default.
• W2105282783 hasPublicationYear "1998" @default.
• W2105282783 type Work @default.
• W2105282783 sameAs 2105282783 @default.
• W2105282783 citedByCount "151" @default.
• W2105282783 countsByYear W21052827832012 @default.
• W2105282783 countsByYear W21052827832013 @default.
• W2105282783 countsByYear W21052827832014 @default.
• W2105282783 countsByYear W21052827832015 @default.
• W2105282783 countsByYear W21052827832016 @default.
• W2105282783 countsByYear W21052827832017 @default.
• W2105282783 countsByYear W21052827832018 @default.
• W2105282783 countsByYear W21052827832019 @default.
• W2105282783 countsByYear W21052827832020 @default.
• W2105282783 countsByYear W21052827832021 @default.
• W2105282783 countsByYear W21052827832022 @default.
• W2105282783 crossrefType "journal-article" @default.
• W2105282783 hasAuthorship W2105282783A5001753331 @default.
• W2105282783 hasAuthorship W2105282783A5002600242 @default.
• W2105282783 hasAuthorship W2105282783A5022942037 @default.
• W2105282783 hasAuthorship W2105282783A5029866856 @default.
• W2105282783 hasAuthorship W2105282783A5038489527 @default.
• W2105282783 hasAuthorship W2105282783A5041976342 @default.
• W2105282783 hasAuthorship W2105282783A5054511388 @default.
• W2105282783 hasBestOaLocation W21052827831 @default.
• W2105282783 hasConcept C104317684 @default.
• W2105282783 hasConcept C114246631 @default.
• W2105282783 hasConcept C119795356 @default.
• W2105282783 hasConcept C142724271 @default.
• W2105282783 hasConcept C178790620 @default.
• W2105282783 hasConcept C181199279 @default.
• W2105282783 hasConcept C185592680 @default.
• W2105282783 hasConcept C204787440 @default.
• W2105282783 hasConcept C2777538855 @default.
• W2105282783 hasConcept C2778004101 @default.
• W2105282783 hasConcept C2778250585 @default.
• W2105282783 hasConcept C2778951431 @default.
• W2105282783 hasConcept C2779107934 @default.
• W2105282783 hasConcept C2780497538 @default.
• W2105282783 hasConcept C526171541 @default.
• W2105282783 hasConcept C538909803 @default.
• W2105282783 hasConcept C55493867 @default.
• W2105282783 hasConcept C555283112 @default.
• W2105282783 hasConcept C62231903 @default.
• W2105282783 hasConcept C71924100 @default.
• W2105282783 hasConcept C86803240 @default.
• W2105282783 hasConcept C98274493 @default.
• W2105282783 hasConceptScore W2105282783C104317684 @default.
• W2105282783 hasConceptScore W2105282783C114246631 @default.
• W2105282783 hasConceptScore W2105282783C119795356 @default.
• W2105282783 hasConceptScore W2105282783C142724271 @default.

• next