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- W2105303945 abstract "Attrition is a major issue in anticancer drug development with up to 95% of drugs tested in Phase I trials not reaching a marketing authorisation making the drug development process enormously costly and inefficient. It is essential that this problem is addressed throughout the whole drug development process to improve efficiency which will ultimately result in increased patient benefit with more profitable drugs. The approach to reduce cancer drug attrition rates must be based on three pillars. The first of these is that there is a need for new pre-clinical models which can act as better predictors of success in clinical trials. Furthermore, clinical trials driven by tumour biology with the incorporation of predictive and pharmacodynamic biomarkers would be beneficial in drug development. Finally, there is a need for increased collaboration to combine the unique strengths between industry, academia and regulators to ensure that the needs of all stakeholders are met." @default.
- W2105303945 created "2016-06-24" @default.
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- W2105303945 creator A5057446858 @default.
- W2105303945 date "2013-02-04" @default.
- W2105303945 modified "2023-09-30" @default.
- W2105303945 title "How can attrition rates be reduced in cancer drug discovery?" @default.
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- W2105303945 doi "https://doi.org/10.1517/17460441.2013.768984" @default.
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