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- W2105311148 abstract "Cholesterol reduction from statin therapy has been one of the greatest public health successes in modern medicine. Simvastatin is among the most commonly used prescription medications. A non-synonymous coding single-nucleotide polymorphism (SNP), rs4149056, in SLCO1B1 markedly increases systemic exposure to simvastatin and the risk of muscle toxicity. This guideline explores the relationship between rs4149056 (c.521T>C, p.V174A) and clinical outcome for all statins. The strength of the evidence is high for myopathy with simvastatin. We limit our recommendations accordingly." @default.
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- W2105311148 date "2012-05-23" @default.
- W2105311148 modified "2023-10-17" @default.
- W2105311148 title "The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy" @default.
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- W2105311148 doi "https://doi.org/10.1038/clpt.2012.57" @default.
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