FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105311467> ?p ?o ?g. }

• W2105311467 endingPage "6413" @default.
• W2105311467 startingPage "6407" @default.
• W2105311467 abstract "Down-regulation of MAP kinase (MAPK) is a universal consequence of fertilization in the animal kingdom, although its role is not known. Here we show that MAPK inactivation is essential for embryos, both vertebrate and invertebrate, to enter first mitosis. Suppressing down-regulation of MAPK at fertilization, for example by constitutively activating the upstream MAPK cascade, specifically suppresses cyclin B-cdc2 kinase activation and its consequence, entry into first mitosis. It thus appears that MAPK functions in meiotic maturation by preventing unfertilized eggs from proceeding into parthenogenetic development. The most general effect of artificially maintaining MAPK activity after fertilization is prevention of the G2 to M-phase transition in the first mitotic cell cycle, even though inappropriate reactivation of MAPK after fertilization may lead to metaphase arrest in vertebrates. Advancing the time of MAPK inactivation in fertilized eggs does not, however, speed up their entry into first mitosis. Thus, sustained activity of MAPK during part of the first mitotic cell cycle is not responsible for late entry of fertilized eggs into first mitosis." @default.
• W2105311467 created "2016-06-24" @default.
• W2105311467 creator A5009481547 @default.
• W2105311467 creator A5020705116 @default.
• W2105311467 creator A5040481848 @default.
• W2105311467 creator A5057250116 @default.
• W2105311467 creator A5080917134 @default.
• W2105311467 date "1997-11-01" @default.
• W2105311467 modified "2023-10-18" @default.
• W2105311467 title "MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle" @default.
• W2105311467 cites W1014442256 @default.
• W2105311467 cites W1036190172 @default.
• W2105311467 cites W1494719693 @default.
• W2105311467 cites W1506402600 @default.
• W2105311467 cites W1597498191 @default.
• W2105311467 cites W1964146094 @default.
• W2105311467 cites W1964511352 @default.
• W2105311467 cites W1975058628 @default.
• W2105311467 cites W1979517998 @default.
• W2105311467 cites W1981341970 @default.
• W2105311467 cites W1995402982 @default.
• W2105311467 cites W1995699753 @default.
• W2105311467 cites W2004912474 @default.
• W2105311467 cites W2014445311 @default.
• W2105311467 cites W2027766408 @default.
• W2105311467 cites W2032840077 @default.
• W2105311467 cites W2043070535 @default.
• W2105311467 cites W2044846732 @default.
• W2105311467 cites W2047178238 @default.
• W2105311467 cites W2048990794 @default.
• W2105311467 cites W2055157702 @default.
• W2105311467 cites W2059623287 @default.
• W2105311467 cites W2071204781 @default.
• W2105311467 cites W2078030700 @default.
• W2105311467 cites W2079223456 @default.
• W2105311467 cites W2081128958 @default.
• W2105311467 cites W2081543364 @default.
• W2105311467 cites W2087512240 @default.
• W2105311467 cites W2091285777 @default.
• W2105311467 cites W2092455067 @default.
• W2105311467 cites W2101500464 @default.
• W2105311467 cites W2104764445 @default.
• W2105311467 cites W2109623711 @default.
• W2105311467 cites W2115823998 @default.
• W2105311467 cites W2124541962 @default.
• W2105311467 cites W2145312934 @default.
• W2105311467 cites W2149785747 @default.
• W2105311467 cites W2155212002 @default.
• W2105311467 cites W2165767435 @default.
• W2105311467 cites W2181852064 @default.
• W2105311467 cites W2183604725 @default.
• W2105311467 cites W2217663772 @default.
• W2105311467 cites W2281226559 @default.
• W2105311467 cites W2288844445 @default.
• W2105311467 cites W271731697 @default.
• W2105311467 cites W93220107 @default.
• W2105311467 cites W98119722 @default.
• W2105311467 cites W987526729 @default.
• W2105311467 doi "https://doi.org/10.1093/emboj/16.21.6407" @default.
• W2105311467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1170247" @default.
• W2105311467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9351823" @default.
• W2105311467 hasPublicationYear "1997" @default.
• W2105311467 type Work @default.
• W2105311467 sameAs 2105311467 @default.
• W2105311467 citedByCount "75" @default.
• W2105311467 countsByYear W21053114672012 @default.
• W2105311467 countsByYear W21053114672013 @default.
• W2105311467 countsByYear W21053114672016 @default.
• W2105311467 countsByYear W21053114672020 @default.
• W2105311467 countsByYear W21053114672021 @default.
• W2105311467 crossrefType "journal-article" @default.
• W2105311467 hasAuthorship W2105311467A5009481547 @default.
• W2105311467 hasAuthorship W2105311467A5020705116 @default.
• W2105311467 hasAuthorship W2105311467A5040481848 @default.
• W2105311467 hasAuthorship W2105311467A5057250116 @default.
• W2105311467 hasAuthorship W2105311467A5080917134 @default.
• W2105311467 hasBestOaLocation W21053114671 @default.
• W2105311467 hasConcept C104317684 @default.
• W2105311467 hasConcept C120504264 @default.
• W2105311467 hasConcept C1491633281 @default.
• W2105311467 hasConcept C184235292 @default.
• W2105311467 hasConcept C2909378205 @default.
• W2105311467 hasConcept C29537977 @default.
• W2105311467 hasConcept C30481170 @default.
• W2105311467 hasConcept C53420372 @default.
• W2105311467 hasConcept C54355233 @default.
• W2105311467 hasConcept C57074206 @default.
• W2105311467 hasConcept C6391034 @default.
• W2105311467 hasConcept C6902291 @default.
• W2105311467 hasConcept C70278784 @default.
• W2105311467 hasConcept C86803240 @default.
• W2105311467 hasConcept C88972607 @default.
• W2105311467 hasConcept C93304396 @default.
• W2105311467 hasConcept C95444343 @default.
• W2105311467 hasConceptScore W2105311467C104317684 @default.
• W2105311467 hasConceptScore W2105311467C120504264 @default.
• W2105311467 hasConceptScore W2105311467C1491633281 @default.
• W2105311467 hasConceptScore W2105311467C184235292 @default.

• next