FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105332519> ?p ?o ?g. }

• W2105332519 endingPage "215" @default.
• W2105332519 startingPage "204" @default.
• W2105332519 abstract "We tested the hypothesis that simultaneous transgenic overexpression of a select quartet of growth factors activates diverse signaling pathways for mobilization and participation of various stem/progenitor cells for cardiogenesis in the infarcted heart. Human insulin growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), stromal cell-derived factor-1 (SDF-1a), and hepatocyte growth factor (HGF) plasmids were synthesized and transfected into skeletal myoblasts (SM) from young male wild-type or transgenic rats expressing green fluorescent protein (GFP). Overexpression of growth factors in transfected SM ((Trans)SM) was confirmed by reverse transcription polymerase chain reaction, western blotting, and fluorescence immunostaining. Using our custom-made growth factor array and western blotting, multiple angiogenic and prosurvival factors were detected in (Trans)SM, including secreted frizzled related protein-1,2,4,5, matrix metalloproteinases-3 and 9, connexin-43, netrin-1, Nos-2, Wnt-3, Akt, MAPK42/44, Stat3, nuclear factor kappa B (NFκB), hypoxia-inducible factor 1 (HIF-1α), and protein kinase C (PKC). The conditioned medium (CM) from (Trans)SM was cytoprotective for cardiomyocytes following H(2)O(2) treatment [P<0.01 vs. CM from native SM ((Nat)SM)], promoted a higher transwell migration of human umbilical cord vein endothelial cells (223.3±1.8, P<0.01) and in vitro tube formation (47.8±1.9, P<0.01). Intramyocardial transplantation of 1.5×10(6) (Trans)SM (group-3) in a rat model of acute myocardial infarction induced extensive mobilization of cMet(+), ckit(+), ckit(+)/GATA(4+), CXCR4(+), CD44(+), CD31(+), and CD59(+) cells into the infarcted heart on day 7 and improved integration of (Trans)SM in the heart compared to (Nat)SM (group 2) (P<0.05). Extensive neomyogenesis and angiogenesis in group-3 (P<0.01 vs. group-2), with resultant attenuation of infarct size (P<0.01 vs. group-2) and improvement in global heart function (P<0.01 vs. group-2) was observed at 8 weeks. In conclusion, simultaneous activation of diverse signaling pathways by overexpression of multiple growth factors caused massive mobilization and homing of stem/progenitor cells from peripheral circulation, the bone marrow, and the heart for accelerated repair of the infarcted myocardium." @default.
• W2105332519 created "2016-06-24" @default.
• W2105332519 creator A5004213502 @default.
• W2105332519 creator A5032353933 @default.
• W2105332519 creator A5049157795 @default.
• W2105332519 creator A5058571380 @default.
• W2105332519 creator A5087456408 @default.
• W2105332519 creator A5091905139 @default.
• W2105332519 date "2013-01-15" @default.
• W2105332519 modified "2023-09-29" @default.
• W2105332519 title "Activation of Diverse Signaling Pathways by Ex-Vivo Delivery of Multiple Cytokines for Myocardial Repair" @default.
• W2105332519 cites W105565805 @default.
• W2105332519 cites W1599022641 @default.
• W2105332519 cites W1968609732 @default.
• W2105332519 cites W1969834344 @default.
• W2105332519 cites W1973940513 @default.
• W2105332519 cites W1982365221 @default.
• W2105332519 cites W1984944884 @default.
• W2105332519 cites W1989583144 @default.
• W2105332519 cites W2000292756 @default.
• W2105332519 cites W2001670129 @default.
• W2105332519 cites W2004907588 @default.
• W2105332519 cites W2008031660 @default.
• W2105332519 cites W2021142885 @default.
• W2105332519 cites W2029108949 @default.
• W2105332519 cites W2038543378 @default.
• W2105332519 cites W2039409077 @default.
• W2105332519 cites W2044953345 @default.
• W2105332519 cites W2056842941 @default.
• W2105332519 cites W2060401959 @default.
• W2105332519 cites W2074789845 @default.
• W2105332519 cites W2075282559 @default.
• W2105332519 cites W2080196370 @default.
• W2105332519 cites W2082676215 @default.
• W2105332519 cites W2084075462 @default.
• W2105332519 cites W2096650620 @default.
• W2105332519 cites W2101334290 @default.
• W2105332519 cites W2108645705 @default.
• W2105332519 cites W2109399800 @default.
• W2105332519 cites W2114736117 @default.
• W2105332519 cites W2114754360 @default.
• W2105332519 cites W2117412164 @default.
• W2105332519 cites W2119841264 @default.
• W2105332519 cites W2126953815 @default.
• W2105332519 cites W2129415222 @default.
• W2105332519 cites W2134704099 @default.
• W2105332519 cites W2141793376 @default.
• W2105332519 cites W2149195526 @default.
• W2105332519 cites W2151722542 @default.
• W2105332519 cites W2152761109 @default.
• W2105332519 cites W2153899938 @default.
• W2105332519 cites W2170871745 @default.
• W2105332519 cites W2171189045 @default.
• W2105332519 cites W4253837043 @default.
• W2105332519 doi "https://doi.org/10.1089/scd.2011.0575" @default.
• W2105332519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3545358" @default.
• W2105332519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22873203" @default.
• W2105332519 hasPublicationYear "2013" @default.
• W2105332519 type Work @default.
• W2105332519 sameAs 2105332519 @default.
• W2105332519 citedByCount "37" @default.
• W2105332519 countsByYear W21053325192012 @default.
• W2105332519 countsByYear W21053325192013 @default.
• W2105332519 countsByYear W21053325192014 @default.
• W2105332519 countsByYear W21053325192015 @default.
• W2105332519 countsByYear W21053325192016 @default.
• W2105332519 countsByYear W21053325192017 @default.
• W2105332519 countsByYear W21053325192018 @default.
• W2105332519 countsByYear W21053325192020 @default.
• W2105332519 countsByYear W21053325192021 @default.
• W2105332519 countsByYear W21053325192022 @default.
• W2105332519 countsByYear W21053325192023 @default.
• W2105332519 crossrefType "journal-article" @default.
• W2105332519 hasAuthorship W2105332519A5004213502 @default.
• W2105332519 hasAuthorship W2105332519A5032353933 @default.
• W2105332519 hasAuthorship W2105332519A5049157795 @default.
• W2105332519 hasAuthorship W2105332519A5058571380 @default.
• W2105332519 hasAuthorship W2105332519A5087456408 @default.
• W2105332519 hasAuthorship W2105332519A5091905139 @default.
• W2105332519 hasBestOaLocation W21053325192 @default.
• W2105332519 hasConcept C153911025 @default.
• W2105332519 hasConcept C167734588 @default.
• W2105332519 hasConcept C170493617 @default.
• W2105332519 hasConcept C2775960820 @default.
• W2105332519 hasConcept C2776996007 @default.
• W2105332519 hasConcept C2777025900 @default.
• W2105332519 hasConcept C502942594 @default.
• W2105332519 hasConcept C55493867 @default.
• W2105332519 hasConcept C86803240 @default.
• W2105332519 hasConcept C95444343 @default.
• W2105332519 hasConceptScore W2105332519C153911025 @default.
• W2105332519 hasConceptScore W2105332519C167734588 @default.
• W2105332519 hasConceptScore W2105332519C170493617 @default.
• W2105332519 hasConceptScore W2105332519C2775960820 @default.
• W2105332519 hasConceptScore W2105332519C2776996007 @default.
• W2105332519 hasConceptScore W2105332519C2777025900 @default.
• W2105332519 hasConceptScore W2105332519C502942594 @default.
• W2105332519 hasConceptScore W2105332519C55493867 @default.

• next