FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105332564> ?p ?o ?g. }

• W2105332564 endingPage "1935" @default.
• W2105332564 startingPage "1927" @default.
• W2105332564 abstract "Abstract It was recently found that osteoblastic cells express TRANCE (tumor necrosis factor-related activation-induced cytokine), a newly identified member of the tumor necrosis factor superfamily, and that expression was increased by calciotropic hormones. Furthermore, soluble recombinant TRANCE induces osteoclast formation and resorption in stroma-free populations of hemopoietic precursor cells. However, overexpression of the decoy receptor osteoprotegerin in vivo shows that there are substantial differences in the sensitivity of different sites to resorption-inhibition, suggesting that either alternative ligands exist or the sensitivity of osteoclasts to TRANCE can be modified by cofactors. We therefore tested the possibility that cofactors might enhance osteoclast formation by TRANCE. We found that the number of tartrate-resistant acid phosphatase-positive and calcitonin receptor-positive cells was increased by a factor of 10 by the presence of PGE2 in the absence of stromal cells. Moreover, although the tartrate-resistant acid phosphatase-positive cells that formed in TRANCE alone were typically mononuclear and poorly spread, the addition of PGE2 induced the formation of large, well spread multinuclear cells. There was an increase in bone resorption that corresponded with the increase in osteoclast number. PGE2 did not synergize with TRANCE for resorption-stimulation in mature cells. 8-Bromo-cAMP showed a similar syngergistic effect on osteoclastic differentiation. Thus, PGE2 appears to stimulate bone resorption through a direct effect on hemopoietic precursors, primarily through a synergistic effect on the ability of TRANCE to induce osteoclastic differentiation." @default.
• W2105332564 created "2016-06-24" @default.
• W2105332564 creator A5016030548 @default.
• W2105332564 creator A5022543438 @default.
• W2105332564 creator A5047977728 @default.
• W2105332564 creator A5079411311 @default.
• W2105332564 creator A5079786990 @default.
• W2105332564 date "1999-04-01" @default.
• W2105332564 modified "2023-09-27" @default.
• W2105332564 title "Prostaglandin E2 Cooperates with TRANCE in Osteoclast Induction from Hemopoietic Precursors: Synergistic Activation of Differentiation, Cell Spreading, and Fusion" @default.
• W2105332564 cites W1527986650 @default.
• W2105332564 cites W1602117004 @default.
• W2105332564 cites W1650001464 @default.
• W2105332564 cites W1965556709 @default.
• W2105332564 cites W1974261403 @default.
• W2105332564 cites W1974402772 @default.
• W2105332564 cites W1977799214 @default.
• W2105332564 cites W1981293067 @default.
• W2105332564 cites W1982749890 @default.
• W2105332564 cites W1983125305 @default.
• W2105332564 cites W1988699977 @default.
• W2105332564 cites W1998688053 @default.
• W2105332564 cites W2000647744 @default.
• W2105332564 cites W2006326408 @default.
• W2105332564 cites W2031078224 @default.
• W2105332564 cites W2032421685 @default.
• W2105332564 cites W2033785962 @default.
• W2105332564 cites W2038558025 @default.
• W2105332564 cites W2040015417 @default.
• W2105332564 cites W2043355910 @default.
• W2105332564 cites W2048299560 @default.
• W2105332564 cites W2053566245 @default.
• W2105332564 cites W2062026488 @default.
• W2105332564 cites W2066484060 @default.
• W2105332564 cites W2070594843 @default.
• W2105332564 cites W2084376887 @default.
• W2105332564 cites W2094374305 @default.
• W2105332564 cites W2097757541 @default.
• W2105332564 cites W2102285032 @default.
• W2105332564 cites W2120837197 @default.
• W2105332564 cites W2124036292 @default.
• W2105332564 cites W2130183308 @default.
• W2105332564 cites W2139996507 @default.
• W2105332564 cites W2164495768 @default.
• W2105332564 cites W2170843968 @default.
• W2105332564 cites W2403583358 @default.
• W2105332564 doi "https://doi.org/10.1210/endo.140.4.6647" @default.
• W2105332564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10098533" @default.
• W2105332564 hasPublicationYear "1999" @default.
• W2105332564 type Work @default.
• W2105332564 sameAs 2105332564 @default.
• W2105332564 citedByCount "137" @default.
• W2105332564 countsByYear W21053325642012 @default.
• W2105332564 countsByYear W21053325642013 @default.
• W2105332564 countsByYear W21053325642014 @default.
• W2105332564 countsByYear W21053325642015 @default.
• W2105332564 countsByYear W21053325642016 @default.
• W2105332564 countsByYear W21053325642018 @default.
• W2105332564 countsByYear W21053325642019 @default.
• W2105332564 countsByYear W21053325642020 @default.
• W2105332564 crossrefType "journal-article" @default.
• W2105332564 hasAuthorship W2105332564A5016030548 @default.
• W2105332564 hasAuthorship W2105332564A5022543438 @default.
• W2105332564 hasAuthorship W2105332564A5047977728 @default.
• W2105332564 hasAuthorship W2105332564A5079411311 @default.
• W2105332564 hasAuthorship W2105332564A5079786990 @default.
• W2105332564 hasBestOaLocation W21053325641 @default.
• W2105332564 hasConcept C104317684 @default.
• W2105332564 hasConcept C109159458 @default.
• W2105332564 hasConcept C126322002 @default.
• W2105332564 hasConcept C134018914 @default.
• W2105332564 hasConcept C146562846 @default.
• W2105332564 hasConcept C148738053 @default.
• W2105332564 hasConcept C16930146 @default.
• W2105332564 hasConcept C170493617 @default.
• W2105332564 hasConcept C17991360 @default.
• W2105332564 hasConcept C181199279 @default.
• W2105332564 hasConcept C185592680 @default.
• W2105332564 hasConcept C21547065 @default.
• W2105332564 hasConcept C2776033226 @default.
• W2105332564 hasConcept C2777956040 @default.
• W2105332564 hasConcept C2780426850 @default.
• W2105332564 hasConcept C28328180 @default.
• W2105332564 hasConcept C55493867 @default.
• W2105332564 hasConcept C673006 @default.
• W2105332564 hasConcept C71924100 @default.
• W2105332564 hasConcept C86803240 @default.
• W2105332564 hasConcept C88045685 @default.
• W2105332564 hasConcept C95444343 @default.
• W2105332564 hasConceptScore W2105332564C104317684 @default.
• W2105332564 hasConceptScore W2105332564C109159458 @default.
• W2105332564 hasConceptScore W2105332564C126322002 @default.
• W2105332564 hasConceptScore W2105332564C134018914 @default.
• W2105332564 hasConceptScore W2105332564C146562846 @default.
• W2105332564 hasConceptScore W2105332564C148738053 @default.
• W2105332564 hasConceptScore W2105332564C16930146 @default.
• W2105332564 hasConceptScore W2105332564C170493617 @default.
• W2105332564 hasConceptScore W2105332564C17991360 @default.

• next