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- W2105343273 endingPage "108" @default.
- W2105343273 startingPage "81" @default.
- W2105343273 abstract "RNA interference (RNAi) can mediate the long- or short-term silencing of gene expression at the DNA, RNA, and/or protein level. Although several triggers of RNAi have been identified, the best characterized of these are small interfering RNAs (siRNAs), which can decrease gene expression through mRNA transcript cleavage, and endogenous microRNAs (miRNAs), which primarily inhibit protein translation. An improved understanding of RNAi has provided new, powerful tools for conducting functional studies in a gene-specific manner. In various applications, RNAi has been used to create model systems, to identify novel molecular targets, to study gene function in a genome-wide fashion, and to create new avenues for clinical therapeutics. Here, we review many of the ongoing applications of RNAi in mammalian and human systems, and discuss how advances in our knowledge of the RNAi machinery have enhanced the use of these technologies." @default.
- W2105343273 created "2016-06-24" @default.
- W2105343273 creator A5052362487 @default.
- W2105343273 creator A5063029120 @default.
- W2105343273 date "2007-09-01" @default.
- W2105343273 modified "2023-10-10" @default.
- W2105343273 title "Applications of RNA Interference in Mammalian Systems" @default.
- W2105343273 cites W1515466910 @default.
- W2105343273 cites W1572667389 @default.
- W2105343273 cites W1611419331 @default.
- W2105343273 cites W1647075334 @default.
- W2105343273 cites W1964093831 @default.
- W2105343273 cites W1966543080 @default.
- W2105343273 cites W1970018160 @default.
- W2105343273 cites W1971643509 @default.
- W2105343273 cites W1972937465 @default.
- W2105343273 cites W1974303227 @default.
- W2105343273 cites W1974512564 @default.
- W2105343273 cites W1977118826 @default.
- W2105343273 cites W1977417679 @default.
- W2105343273 cites W1977733607 @default.
- W2105343273 cites W1977915489 @default.
- W2105343273 cites W1978337436 @default.
- W2105343273 cites W1979428788 @default.
- W2105343273 cites W1979519758 @default.
- W2105343273 cites W1979844428 @default.
- W2105343273 cites W1985184080 @default.
- W2105343273 cites W1985309114 @default.
- W2105343273 cites W1985563073 @default.
- W2105343273 cites W1988142389 @default.
- W2105343273 cites W1989013927 @default.
- W2105343273 cites W1989407131 @default.
- W2105343273 cites W1996163490 @default.
- W2105343273 cites W1997045496 @default.
- W2105343273 cites W1998119441 @default.
- W2105343273 cites W1998661629 @default.
- W2105343273 cites W1999596958 @default.
- W2105343273 cites W1999605403 @default.
- W2105343273 cites W2000658520 @default.
- W2105343273 cites W2004817863 @default.
- W2105343273 cites W2005735769 @default.
- W2105343273 cites W2006447428 @default.
- W2105343273 cites W2006745281 @default.
- W2105343273 cites W2006797972 @default.
- W2105343273 cites W2007811248 @default.
- W2105343273 cites W2008585495 @default.
- W2105343273 cites W2008759459 @default.
- W2105343273 cites W2011480379 @default.
- W2105343273 cites W2012453729 @default.
- W2105343273 cites W2012547585 @default.
- W2105343273 cites W2015511149 @default.
- W2105343273 cites W2016246269 @default.
- W2105343273 cites W2017642141 @default.
- W2105343273 cites W2019631541 @default.
- W2105343273 cites W2020255631 @default.
- W2105343273 cites W2020368715 @default.
- W2105343273 cites W2025678021 @default.
- W2105343273 cites W2029653860 @default.
- W2105343273 cites W2029827106 @default.
- W2105343273 cites W2030354478 @default.
- W2105343273 cites W2035930185 @default.
- W2105343273 cites W2037067282 @default.
- W2105343273 cites W2042739691 @default.
- W2105343273 cites W2042931566 @default.
- W2105343273 cites W2043641895 @default.
- W2105343273 cites W2043828851 @default.
- W2105343273 cites W2047922381 @default.
- W2105343273 cites W2048607934 @default.
- W2105343273 cites W2052280803 @default.
- W2105343273 cites W2054406918 @default.
- W2105343273 cites W2056561005 @default.
- W2105343273 cites W2059557106 @default.
- W2105343273 cites W2061117911 @default.
- W2105343273 cites W2065221771 @default.
- W2105343273 cites W2066172679 @default.
- W2105343273 cites W2066606615 @default.
- W2105343273 cites W2067087475 @default.
- W2105343273 cites W2068010171 @default.
- W2105343273 cites W2069608350 @default.
- W2105343273 cites W2071596792 @default.
- W2105343273 cites W2072543946 @default.
- W2105343273 cites W2075275335 @default.
- W2105343273 cites W2076136918 @default.
- W2105343273 cites W2078342148 @default.
- W2105343273 cites W2079247052 @default.
- W2105343273 cites W2080407932 @default.
- W2105343273 cites W2080423827 @default.
- W2105343273 cites W2080849576 @default.
- W2105343273 cites W2082213106 @default.
- W2105343273 cites W2083381199 @default.
- W2105343273 cites W2084828626 @default.
- W2105343273 cites W2084851425 @default.
- W2105343273 cites W2090822519 @default.
- W2105343273 cites W2091245078 @default.
- W2105343273 cites W2092828528 @default.
- W2105343273 cites W2093008096 @default.
- W2105343273 cites W2095151181 @default.
- W2105343273 cites W2099956255 @default.