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- W2105352010 abstract "Down's syndrome (DS), caused by trisomy of human chromosome 21, is the most common genetic cause of intellectual disability. Here we use induced pluripotent stem cells (iPSCs) derived from DS patients to identify a role for astrocytes in DS pathogenesis. DS astroglia exhibit higher levels of reactive oxygen species and lower levels of synaptogenic molecules. Astrocyte-conditioned medium collected from DS astroglia causes toxicity to neurons, and fails to promote neuronal ion channel maturation and synapse formation. Transplantation studies show that DS astroglia do not promote neurogenesis of endogenous neural stem cells in vivo. We also observed abnormal gene expression profiles from DS astroglia. Finally, we show that the FDA-approved antibiotic drug, minocycline, partially corrects the pathological phenotypes of DS astroglia by specifically modulating the expression of S100B, GFAP, inducible nitric oxide synthase, and thrombospondins 1 and 2 in DS astroglia. Our studies shed light on the pathogenesis and possible treatment of DS by targeting astrocytes with a clinically available drug." @default.
- W2105352010 created "2016-06-24" @default.
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- W2105352010 date "2014-07-18" @default.
- W2105352010 modified "2023-10-16" @default.
- W2105352010 title "Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells" @default.
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- W2105352010 cites W1994974752 @default.
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- W2105352010 cites W2020657007 @default.
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- W2105352010 cites W2065709540 @default.
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- W2105352010 cites W2083830460 @default.
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- W2105352010 doi "https://doi.org/10.1038/ncomms5430" @default.
- W2105352010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4109022" @default.
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