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• W2105358032 abstract "There are many indications that neurogenesis is impaired in Parkinson's disease, which might be due to a lack of dopamine in the subventricular zone. An impairment in neurogenesis may have negative consequences for the development of new therapeutic approaches in Parkinson's disease, as neural stem cells are a potential source for endogenous repair. In this study, we examined the subventricular zone of 10 patients with Parkinson's disease and 10 age- and sex-matched controls for proliferation and neural stem cell numbers. We also included five cases with incidental Lewy body disease, which showed Parkinson's disease pathology but no clinical symptoms and thus did not receive dopaminergic treatment. We quantified the neural stem cell number and proliferative capacity in the subventricular zone of these three donor groups. We found subventricular neural stem cells in each donor, with a high variation in number. We did not observe significant differences in neural stem cell number or in proliferation between the groups. Additionally, we were able to culture neural stem cells from post-mortem brain of several patients with Parkinson's disease, confirming the presence of viable neural stem cells in these brains. We have also examined the subventricular zone of a chronic, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model, and again found no effect of dopaminergic denervation on precursor proliferation. Lastly, we investigated the proliferation capacity of two different human neural stem cell lines in response to dopamine. Both cell lines did not respond with a change in proliferation to treatment with dopamine agonists and an antagonist. In summary, the adult neural stem cell pool in the subventricular zone was not clearly affected in the human parkinsonian brain or a Parkinson's disease mouse model. Furthermore, we did not find evidence that dopamine has a direct effect on human neural stem cell proliferation in vitro. Thus, we conclude that the number of adult neural stem cells is probably not diminished in the parkinsonian brain and that dopamine depletion most likely has no effect on human neural stem cells." @default.
• W2105358032 created "2016-06-24" @default.
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• W2105358032 date "2011-11-01" @default.
• W2105358032 modified "2023-10-01" @default.
• W2105358032 title "The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain" @default.
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• W2105358032 cites W1950392238 @default.
• W2105358032 cites W1964173716 @default.
• W2105358032 cites W1966148111 @default.
• W2105358032 cites W1968536863 @default.
• W2105358032 cites W1973174453 @default.
• W2105358032 cites W1980940171 @default.
• W2105358032 cites W1986083929 @default.
• W2105358032 cites W1987980866 @default.
• W2105358032 cites W1989696297 @default.
• W2105358032 cites W1992588067 @default.
• W2105358032 cites W1993165361 @default.
• W2105358032 cites W2004030615 @default.
• W2105358032 cites W2007609810 @default.
• W2105358032 cites W2007746109 @default.
• W2105358032 cites W2009128664 @default.
• W2105358032 cites W2009386574 @default.
• W2105358032 cites W2012236861 @default.
• W2105358032 cites W2014692203 @default.
• W2105358032 cites W2016614847 @default.
• W2105358032 cites W2017690889 @default.
• W2105358032 cites W2021902440 @default.
• W2105358032 cites W2022602726 @default.
• W2105358032 cites W2022834361 @default.
• W2105358032 cites W2022923808 @default.
• W2105358032 cites W2023128367 @default.
• W2105358032 cites W2023754965 @default.
• W2105358032 cites W2027132385 @default.
• W2105358032 cites W2028088798 @default.
• W2105358032 cites W2028832381 @default.
• W2105358032 cites W2048167722 @default.
• W2105358032 cites W2050128450 @default.
• W2105358032 cites W2052742260 @default.
• W2105358032 cites W2057608998 @default.
• W2105358032 cites W2059916239 @default.
• W2105358032 cites W2060756968 @default.
• W2105358032 cites W2066553255 @default.
• W2105358032 cites W2069852866 @default.
• W2105358032 cites W2071391660 @default.
• W2105358032 cites W2073449985 @default.
• W2105358032 cites W2073566389 @default.
• W2105358032 cites W2075945604 @default.
• W2105358032 cites W2077439063 @default.
• W2105358032 cites W2082670534 @default.
• W2105358032 cites W2089651110 @default.
• W2105358032 cites W2090644196 @default.
• W2105358032 cites W2096340837 @default.
• W2105358032 cites W2099594951 @default.
• W2105358032 cites W2109120242 @default.
• W2105358032 cites W2109355324 @default.
• W2105358032 cites W2122163242 @default.
• W2105358032 cites W2123285567 @default.
• W2105358032 cites W2124446289 @default.
• W2105358032 cites W2135578489 @default.
• W2105358032 cites W2144186309 @default.
• W2105358032 cites W2144923212 @default.
• W2105358032 cites W2146307538 @default.
• W2105358032 cites W2147800643 @default.
• W2105358032 cites W2155228504 @default.
• W2105358032 cites W2155644513 @default.
• W2105358032 cites W2157617823 @default.
• W2105358032 cites W2158817049 @default.
• W2105358032 cites W2161387455 @default.
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• W2105358032 cites W2331306569 @default.
• W2105358032 cites W2398535294 @default.
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• W2105358032 doi "https://doi.org/10.1093/brain/awr256" @default.
• W2105358032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22075520" @default.
• W2105358032 hasPublicationYear "2011" @default.
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