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• W2105364483 endingPage "138" @default.
• W2105364483 startingPage "129" @default.
• W2105364483 abstract "Natural killer (NK) cells can spontaneously lyse certain virally infected and transformed cells. However, early in immune responses NK cells are further activated and recruited to tissue sites where they perform effector functions. This process is dependent on cytokines, but it is unclear if it is regulated by NK cell recognition of susceptible target cells. We show here that infiltration of activated NK cells into the peritoneal cavity in response to tumor cells is controlled by the tumor major histocompatibility complex (MHC) class I phenotype. Tumor cells lacking appropriate MHC class I expression induced NK cell infiltration, cytotoxic activation, and induction of transcription of interferon γ in NK cells. The induction of these responses was inhibited by restoration of tumor cell MHC class I expression. The NK cells responding to MHC class I–deficient tumor cells were ∼10 times as active as endogenous NK cells on a per cell basis. Although these effector cells showed a typical NK specificity in that they preferentially killed MHC class I–deficient cells, this specificity was even more distinct during induction of the intraperitoneal response. Observations are discussed in relation to a possible adaptive component of the NK response, i.e., recruitment/activation in response to challenges that only NK cells are able to neutralize." @default.
• W2105364483 created "2016-06-24" @default.
• W2105364483 creator A5000011997 @default.
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• W2105364483 date "2000-01-03" @default.
• W2105364483 modified "2023-10-14" @default.
• W2105364483 title "Recruitment and Activation of Natural Killer (Nk) Cells in Vivo Determined by the Target Cell Phenotype" @default.
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• W2105364483 doi "https://doi.org/10.1084/jem.191.1.129" @default.
• W2105364483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2195802" @default.
• W2105364483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10620611" @default.
• W2105364483 hasPublicationYear "2000" @default.
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