FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105367923> ?p ?o ?g. }

• W2105367923 endingPage "51" @default.
• W2105367923 startingPage "45" @default.
• W2105367923 abstract "To compare in vitro expression of beta 1, beta 3, and beta 4 integrins in normal fibroblast-like synoviocytes (FBS) and in FBS from rheumatoid arthritis (RA) synovium and to investigate the adhesion of normal FBS and RA-FBS to the integrin binding extracellular matrix (ECM) proteins: collagen type IV, fibronectin, laminin, and tenascin.Expression of integrin receptors of cultured FBS was detected by flow cytometry. Attachment of FBS to ECM proteins was quantified by adhesion assays. Inhibition studies were performed using monoclonal antibodies to the integrin subunits.Compared with normal FBS, RA-FBS showed increased expression of alpha 1 to alpha 6, beta 1, and beta 4 integrin subunits and enhanced binding of ECM proteins. Binding to ECM proteins was partly or completely blocked by an anti-beta 1 integrin antibody and antibodies to alpha 3, alpha 5, and alpha 6 integrin subunits. The blocking efficiency was significantly (P < 0.05) higher in RA-FBS than in normal FBS.The enhanced expression of the beta 1 integrin receptors on cultured RA-FBS correlated with increased attachment to ECM proteins. Adhesion of normal and RA-FBS to ECM proteins is mediated through beta 1 integrin receptors. Therefore, the tight binding of rheumatoid FBS to the matrix via beta 1 integrins might play a role in ECM remodelling in the rheumatoid process in vivo." @default.
• W2105367923 created "2016-06-24" @default.
• W2105367923 creator A5001293339 @default.
• W2105367923 creator A5016364328 @default.
• W2105367923 creator A5021321390 @default.
• W2105367923 creator A5033324672 @default.
• W2105367923 creator A5059795103 @default.
• W2105367923 creator A5066640097 @default.
• W2105367923 creator A5070252825 @default.
• W2105367923 date "1997-01-01" @default.
• W2105367923 modified "2023-10-12" @default.
• W2105367923 title "Increased expression of integrins on fibroblast-like synoviocytes from rheumatoid arthritis in vitro correlates with enhanced binding to extracellular matrix proteins" @default.
• W2105367923 cites W1604526865 @default.
• W2105367923 cites W1608511206 @default.
• W2105367923 cites W1831734000 @default.
• W2105367923 cites W1872270044 @default.
• W2105367923 cites W1898686169 @default.
• W2105367923 cites W1933744724 @default.
• W2105367923 cites W1981265109 @default.
• W2105367923 cites W1982034123 @default.
• W2105367923 cites W2029231027 @default.
• W2105367923 cites W2036145275 @default.
• W2105367923 cites W2036591069 @default.
• W2105367923 cites W2057049103 @default.
• W2105367923 cites W2062926268 @default.
• W2105367923 cites W2064484362 @default.
• W2105367923 cites W2081611348 @default.
• W2105367923 cites W2083800286 @default.
• W2105367923 cites W2090755901 @default.
• W2105367923 cites W2102193002 @default.
• W2105367923 cites W2116178029 @default.
• W2105367923 cites W2147053487 @default.
• W2105367923 cites W2152348310 @default.
• W2105367923 cites W2157852641 @default.
• W2105367923 cites W216108678 @default.
• W2105367923 cites W2161140556 @default.
• W2105367923 cites W2162700552 @default.
• W2105367923 cites W2267311437 @default.
• W2105367923 cites W2398280696 @default.
• W2105367923 cites W2402777278 @default.
• W2105367923 cites W2407499820 @default.
• W2105367923 cites W2416481240 @default.
• W2105367923 cites W2427483166 @default.
• W2105367923 cites W2460725884 @default.
• W2105367923 cites W2917429630 @default.
• W2105367923 doi "https://doi.org/10.1136/ard.56.1.45" @default.
• W2105367923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1752256" @default.
• W2105367923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9059141" @default.
• W2105367923 hasPublicationYear "1997" @default.
• W2105367923 type Work @default.
• W2105367923 sameAs 2105367923 @default.
• W2105367923 citedByCount "88" @default.
• W2105367923 countsByYear W21053679232012 @default.
• W2105367923 countsByYear W21053679232013 @default.
• W2105367923 countsByYear W21053679232014 @default.
• W2105367923 countsByYear W21053679232015 @default.
• W2105367923 countsByYear W21053679232016 @default.
• W2105367923 countsByYear W21053679232017 @default.
• W2105367923 countsByYear W21053679232018 @default.
• W2105367923 countsByYear W21053679232019 @default.
• W2105367923 countsByYear W21053679232020 @default.
• W2105367923 countsByYear W21053679232021 @default.
• W2105367923 countsByYear W21053679232022 @default.
• W2105367923 countsByYear W21053679232023 @default.
• W2105367923 crossrefType "journal-article" @default.
• W2105367923 hasAuthorship W2105367923A5001293339 @default.
• W2105367923 hasAuthorship W2105367923A5016364328 @default.
• W2105367923 hasAuthorship W2105367923A5021321390 @default.
• W2105367923 hasAuthorship W2105367923A5033324672 @default.
• W2105367923 hasAuthorship W2105367923A5059795103 @default.
• W2105367923 hasAuthorship W2105367923A5066640097 @default.
• W2105367923 hasAuthorship W2105367923A5070252825 @default.
• W2105367923 hasBestOaLocation W21053679231 @default.
• W2105367923 hasConcept C119524353 @default.
• W2105367923 hasConcept C153911025 @default.
• W2105367923 hasConcept C16224149 @default.
• W2105367923 hasConcept C170493617 @default.
• W2105367923 hasConcept C171779818 @default.
• W2105367923 hasConcept C185592680 @default.
• W2105367923 hasConcept C189165786 @default.
• W2105367923 hasConcept C195687474 @default.
• W2105367923 hasConcept C203014093 @default.
• W2105367923 hasConcept C2777738151 @default.
• W2105367923 hasConcept C2779814568 @default.
• W2105367923 hasConcept C553184892 @default.
• W2105367923 hasConcept C55493867 @default.
• W2105367923 hasConcept C86492073 @default.
• W2105367923 hasConcept C86803240 @default.
• W2105367923 hasConcept C95444343 @default.
• W2105367923 hasConceptScore W2105367923C119524353 @default.
• W2105367923 hasConceptScore W2105367923C153911025 @default.
• W2105367923 hasConceptScore W2105367923C16224149 @default.
• W2105367923 hasConceptScore W2105367923C170493617 @default.
• W2105367923 hasConceptScore W2105367923C171779818 @default.
• W2105367923 hasConceptScore W2105367923C185592680 @default.
• W2105367923 hasConceptScore W2105367923C189165786 @default.
• W2105367923 hasConceptScore W2105367923C195687474 @default.
• W2105367923 hasConceptScore W2105367923C203014093 @default.

• next