FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105370069> ?p ?o ?g. }

• W2105370069 endingPage "502" @default.
• W2105370069 startingPage "491" @default.
• W2105370069 abstract "Interleukin-12 (IL-12) is a potent antitumoral cytokine, but high doses are toxic. Herein, we demonstrate that combinational transduction of IL-12 and CC-chemokine ligand-27 (CCL27) genes into pre-existing murine OV-HM ovarian carcinoma and Meth-A fibrosarcoma, by using RGD fiber-mutant adenoviral vectors, could induce tumor regression and relieve systemic side effects more effectively than either treatment alone. The antitumor activity of the IL-12 and CCL27 combination treatment was T-cell-dependent, and development of long-term specific immunity was confirmed in rechallenge experiments. Immunohistochemical analysis of tumors transduced with CCL27 gene alone or cotransduced with IL-12 and CCL27 genes showed significant increases in numbers of infiltrating CD3+ T cells, which included both CD4+ and CD8+ cells. Additionally, cotransduction with IL-12 and CCL27 genes could more efficiently activate tumor-infiltrating immune cells than transduction with CCL27 alone, as determined by the frequency of perforin-positive cells and expression levels of IFN-γ. Furthermore, mice treated with the IL-12 and CCL27 combination compared with those treated with IL-12 alone showed milder pathological changes, for example, lymphocyte infiltration and extramedullary hematopoiesis, in lung, liver and spleen. Our data provide evidence that combinational in vivo transduction with IL-12 and CCL27 genes is a promising approach for the development of cancer immunogene therapy that can simultaneously recruit and activate tumor-infiltrating immune cells." @default.
• W2105370069 created "2016-06-24" @default.
• W2105370069 creator A5005228015 @default.
• W2105370069 creator A5008699926 @default.
• W2105370069 creator A5009898152 @default.
• W2105370069 creator A5011409446 @default.
• W2105370069 creator A5018600874 @default.
• W2105370069 creator A5042435148 @default.
• W2105370069 creator A5056435839 @default.
• W2105370069 creator A5056783345 @default.
• W2105370069 creator A5061307882 @default.
• W2105370069 creator A5069468154 @default.
• W2105370069 creator A5080580138 @default.
• W2105370069 creator A5084909567 @default.
• W2105370069 date "2007-01-04" @default.
• W2105370069 modified "2023-10-18" @default.
• W2105370069 title "Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer" @default.
• W2105370069 cites W1489870404 @default.
• W2105370069 cites W1519962349 @default.
• W2105370069 cites W1546278502 @default.
• W2105370069 cites W1578692400 @default.
• W2105370069 cites W1600662889 @default.
• W2105370069 cites W1644502582 @default.
• W2105370069 cites W1751960924 @default.
• W2105370069 cites W1967509070 @default.
• W2105370069 cites W1970847065 @default.
• W2105370069 cites W1972922050 @default.
• W2105370069 cites W1975353758 @default.
• W2105370069 cites W1977817262 @default.
• W2105370069 cites W1979514172 @default.
• W2105370069 cites W1983467202 @default.
• W2105370069 cites W1991148746 @default.
• W2105370069 cites W1996690207 @default.
• W2105370069 cites W2006178861 @default.
• W2105370069 cites W2026544727 @default.
• W2105370069 cites W2038260086 @default.
• W2105370069 cites W2049466185 @default.
• W2105370069 cites W2050219665 @default.
• W2105370069 cites W2056859114 @default.
• W2105370069 cites W2060635318 @default.
• W2105370069 cites W2064074518 @default.
• W2105370069 cites W2070437307 @default.
• W2105370069 cites W2073866116 @default.
• W2105370069 cites W2095484603 @default.
• W2105370069 cites W2098866087 @default.
• W2105370069 cites W2102401914 @default.
• W2105370069 cites W2107560602 @default.
• W2105370069 cites W2119969523 @default.
• W2105370069 cites W2120303897 @default.
• W2105370069 cites W2125580285 @default.
• W2105370069 cites W2135912626 @default.
• W2105370069 cites W2162013743 @default.
• W2105370069 cites W2167429078 @default.
• W2105370069 cites W2174465537 @default.
• W2105370069 cites W2320012522 @default.
• W2105370069 cites W2415300244 @default.
• W2105370069 cites W4250647025 @default.
• W2105370069 cites W97158386 @default.
• W2105370069 doi "https://doi.org/10.1038/sj.gt.3302892" @default.
• W2105370069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17203106" @default.
• W2105370069 hasPublicationYear "2007" @default.
• W2105370069 type Work @default.
• W2105370069 sameAs 2105370069 @default.
• W2105370069 citedByCount "21" @default.
• W2105370069 countsByYear W21053700692012 @default.
• W2105370069 countsByYear W21053700692013 @default.
• W2105370069 countsByYear W21053700692016 @default.
• W2105370069 countsByYear W21053700692017 @default.
• W2105370069 countsByYear W21053700692018 @default.
• W2105370069 countsByYear W21053700692020 @default.
• W2105370069 countsByYear W21053700692021 @default.
• W2105370069 countsByYear W21053700692022 @default.
• W2105370069 crossrefType "journal-article" @default.
• W2105370069 hasAuthorship W2105370069A5005228015 @default.
• W2105370069 hasAuthorship W2105370069A5008699926 @default.
• W2105370069 hasAuthorship W2105370069A5009898152 @default.
• W2105370069 hasAuthorship W2105370069A5011409446 @default.
• W2105370069 hasAuthorship W2105370069A5018600874 @default.
• W2105370069 hasAuthorship W2105370069A5042435148 @default.
• W2105370069 hasAuthorship W2105370069A5056435839 @default.
• W2105370069 hasAuthorship W2105370069A5056783345 @default.
• W2105370069 hasAuthorship W2105370069A5061307882 @default.
• W2105370069 hasAuthorship W2105370069A5069468154 @default.
• W2105370069 hasAuthorship W2105370069A5080580138 @default.
• W2105370069 hasAuthorship W2105370069A5084909567 @default.
• W2105370069 hasBestOaLocation W21053700691 @default.
• W2105370069 hasConcept C104317684 @default.
• W2105370069 hasConcept C111599444 @default.
• W2105370069 hasConcept C154317977 @default.
• W2105370069 hasConcept C167672396 @default.
• W2105370069 hasConcept C202751555 @default.
• W2105370069 hasConcept C203014093 @default.
• W2105370069 hasConcept C2778690821 @default.
• W2105370069 hasConcept C502942594 @default.
• W2105370069 hasConcept C55493867 @default.
• W2105370069 hasConcept C86803240 @default.
• W2105370069 hasConcept C8891405 @default.
• W2105370069 hasConceptScore W2105370069C104317684 @default.

• next