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• W2105387934 abstract "The amphiphilic fullerene monomer (AF-1) consists of a buckyball cage to which a Newkome-like dendrimer unit and five lipophilic C12 chains positioned octahedrally to the dendrimer unit are attached. In this study, we report a novel fullerene-based liposome termed 'buckysome' that is water soluble and forms stable spherical nanometer sized vesicles. Cryogenic electron microscopy (Cryo-EM), transmission electron microscopy (TEM), and dynamic light scattering (DLS) studies were used to characterize the different supra-molecular structures readily formed from the fullerene monomers under varying pH, aqueous solvents, and preparative conditions.Electron microscopy results indicate the formation of bilayer membranes with a width of ~6.5 nm, consistent with previously reported molecular dynamics simulations. Cryo-EM indicates the formation of large (400 nm diameter) multilamellar, liposome-like vesicles and unilamellar vesicles in the size range of 50-150 nm diameter. In addition, complex networks of cylindrical, tube-like aggregates with varying lengths and packing densities were observed. Under controlled experimental conditions, high concentrations of spherical vesicles could be formed. In vitro results suggest that these supra-molecular structures impose little to no toxicity. Cytotoxicity of 10-200 muM buckysomes were assessed in various cell lines. Ongoing studies are aimed at understanding cellular internalization of these nanoparticle aggregates.In this current study, we have designed a core platform based on a novel amphiphilic fullerene nanostructure, which readily assembles into supra-molecular structures. This delivery vector might provide promising features such as ease of preparation, long-term stability and controlled release." @default.
• W2105387934 created "2016-06-24" @default.
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• W2105387934 date "2007-08-02" @default.
• W2105387934 modified "2023-10-16" @default.
• W2105387934 title "Self assembly of amphiphilic C60 fullerene derivatives into nanoscale supramolecular structures" @default.
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• W2105387934 doi "https://doi.org/10.1186/1477-3155-5-6" @default.
• W2105387934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2000908" @default.
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• W2105387934 hasPublicationYear "2007" @default.
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