Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105388675> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2105388675 endingPage "1191" @default.
- W2105388675 startingPage "1185" @default.
- W2105388675 abstract "Blood-brain barrier integrity during cardiopulmonary resuscitation may be important because of the potential effects of adrenergic agonists administered during arrest on cerebral metabolism and the cerebral vasculature. As an index of blood-brain barrier permeability to small molecules, we measured the brain uptake of [14C]alpha-aminoisobutyric acid during a 10-minute period in 25 anesthetized dogs. To correct for the amount of carbon-14 label in the plasma space, we administered [3H] inulin 2 minutes before death. The mean transfer coefficient in 14 brain regions of five control dogs ranged from 0.002 to 0.007 ml/g/min. After 8 (n = 15) or 15 (n = 5) minutes of cardiac arrest, external chest compression was instituted to maintain aortic blood pressure above 60 mm Hg. The transfer coefficient was not elevated during chest compression (n = 10), immediately following defibrillation (n = 5), or 4 hours after resuscitation (n = 5); in some brain regions the transfer coefficient decreased. However, the decrease in the transfer coefficient was proportional to the decrease in the cerebral plasma volume as measured by the ratio of the [3H]inulin concentration in the tissue to that in the plasma. Thus, it is unlikely that a decrease in capillary surface area masked an increase in blood-brain barrier permeability. Therefore, we found no evidence of blood-brain barrier disruption during or after cardiopulmonary resuscitation in dogs. Despite the large phasic increases in sagittal sinus pressure associated with external chest compression, concurrent increases in cerebrospinal fluid pressure apparently protect the microcirculation from increased transmural pressure." @default.
- W2105388675 created "2016-06-24" @default.
- W2105388675 creator A5006130007 @default.
- W2105388675 creator A5041130115 @default.
- W2105388675 creator A5060319184 @default.
- W2105388675 creator A5089081763 @default.
- W2105388675 date "1990-08-01" @default.
- W2105388675 modified "2023-10-16" @default.
- W2105388675 title "Blood-brain barrier integrity during cardiopulmonary resuscitation in dogs." @default.
- W2105388675 cites W1971131007 @default.
- W2105388675 cites W1976490782 @default.
- W2105388675 cites W2039071874 @default.
- W2105388675 cites W2043905666 @default.
- W2105388675 cites W2053172595 @default.
- W2105388675 cites W2054482783 @default.
- W2105388675 cites W2060821715 @default.
- W2105388675 cites W2077468177 @default.
- W2105388675 cites W2077826388 @default.
- W2105388675 cites W2082888456 @default.
- W2105388675 cites W2087367220 @default.
- W2105388675 cites W2134670490 @default.
- W2105388675 doi "https://doi.org/10.1161/01.str.21.8.1185" @default.
- W2105388675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2389299" @default.
- W2105388675 hasPublicationYear "1990" @default.
- W2105388675 type Work @default.
- W2105388675 sameAs 2105388675 @default.
- W2105388675 citedByCount "29" @default.
- W2105388675 countsByYear W21053886752014 @default.
- W2105388675 countsByYear W21053886752019 @default.
- W2105388675 crossrefType "journal-article" @default.
- W2105388675 hasAuthorship W2105388675A5006130007 @default.
- W2105388675 hasAuthorship W2105388675A5041130115 @default.
- W2105388675 hasAuthorship W2105388675A5060319184 @default.
- W2105388675 hasAuthorship W2105388675A5089081763 @default.
- W2105388675 hasBestOaLocation W21053886751 @default.
- W2105388675 hasConcept C113045295 @default.
- W2105388675 hasConcept C126322002 @default.
- W2105388675 hasConcept C12722491 @default.
- W2105388675 hasConcept C164705383 @default.
- W2105388675 hasConcept C2777055891 @default.
- W2105388675 hasConcept C2778165595 @default.
- W2105388675 hasConcept C2778402981 @default.
- W2105388675 hasConcept C42219234 @default.
- W2105388675 hasConcept C529278444 @default.
- W2105388675 hasConcept C71924100 @default.
- W2105388675 hasConceptScore W2105388675C113045295 @default.
- W2105388675 hasConceptScore W2105388675C126322002 @default.
- W2105388675 hasConceptScore W2105388675C12722491 @default.
- W2105388675 hasConceptScore W2105388675C164705383 @default.
- W2105388675 hasConceptScore W2105388675C2777055891 @default.
- W2105388675 hasConceptScore W2105388675C2778165595 @default.
- W2105388675 hasConceptScore W2105388675C2778402981 @default.
- W2105388675 hasConceptScore W2105388675C42219234 @default.
- W2105388675 hasConceptScore W2105388675C529278444 @default.
- W2105388675 hasConceptScore W2105388675C71924100 @default.
- W2105388675 hasIssue "8" @default.
- W2105388675 hasLocation W21053886751 @default.
- W2105388675 hasLocation W21053886752 @default.
- W2105388675 hasOpenAccess W2105388675 @default.
- W2105388675 hasPrimaryLocation W21053886751 @default.
- W2105388675 hasRelatedWork W1557478846 @default.
- W2105388675 hasRelatedWork W2010553668 @default.
- W2105388675 hasRelatedWork W2021506741 @default.
- W2105388675 hasRelatedWork W2027936207 @default.
- W2105388675 hasRelatedWork W2067806978 @default.
- W2105388675 hasRelatedWork W2080572230 @default.
- W2105388675 hasRelatedWork W2080630228 @default.
- W2105388675 hasRelatedWork W2330092428 @default.
- W2105388675 hasRelatedWork W2405278999 @default.
- W2105388675 hasRelatedWork W2559392934 @default.
- W2105388675 hasVolume "21" @default.
- W2105388675 isParatext "false" @default.
- W2105388675 isRetracted "false" @default.
- W2105388675 magId "2105388675" @default.
- W2105388675 workType "article" @default.