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- W2105389620 abstract "The earlier finding of an antagonistic effect of human plasma albumin on the insulin-stimulated glucose uptake of the cut rat diaphragm in vitro has been confirmed. In the intact rat hemidiaphragm in vitro 1 mU of insulin per ml caused a marked increase (40–70 per cent) of the incorporation of 14C-labelled phenylalanine into protein. Adding 5 per cent albumin caused a significant reduction of this insulin effect. Intraperitoneal injection of 1mU of insulin caused a marked increase in glycogen content and 14C-labelled glucose incorporation into glycogen in the diaphragm muscle in vivo. This effect was antagonized by the simultaneous injection of 50–150 mg of “antagonistic” albumin; control injections of “non-antagonistic” albumin had no such effect. Increasing the insulin dose 10-fold abolished the antagonistic effect of the albumin. The result support the assumption that the “synalbumin” antagonist is a physiological antagonist of insulin action." @default.
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- W2105389620 date "1966-03-01" @default.
- W2105389620 modified "2023-09-25" @default.
- W2105389620 title "Insulin Antagonistic Effect of Human Plasma Albumin on Protein Synthesis in vitro and on Glycogen Synthesis in vivo in the Rat Diaphragm Muscle" @default.
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- W2105389620 doi "https://doi.org/10.1111/j.1748-1716.1966.tb03203.x" @default.
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