Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105393937> ?p ?o ?g. }
- W2105393937 endingPage "20739" @default.
- W2105393937 startingPage "20723" @default.
- W2105393937 abstract "Hypoxic stress drives cancer progression by causing a transcriptional reprogramming. Recently, KIAA1199 was discovered to be a cell-migration inducing protein (renamed CEMIP) that is upregulated in human cancers. However, the mechanism of induction of CEMIP in cancer was hitherto unknown. Here we demonstrate that hypoxia induces CEMIP expression leading to enhanced cell migration. Immunohistochemistry of human colon cancer tissues revealed that CEMIP is upregulated in cancer cells located at the invasive front or in the submucosa. CEMIP localization inversely correlated with E-cadherin expression, which is characteristic of the epithelial-to-mesenchymal transition. Mechanistically, hypoxia-inducible-factor-2α (HIF-2α), but not HIF-1α binds directly to the hypoxia response element within the CEMIP promoter region resulting in increased CEMIP expression. Functional characterization reveals that CEMIP is a downstream effector of HIF-2α-mediated cell migration. Expression of CEMIP was demonstrated to negatively correlate with the expression of Jarid1A, a histone demethylase that removes methyl groups from H3K4me3 (an activation marker for transcription), resulting in altered gene repression. Low oxygen tension inhibits the function of Jarid1A, leading to increased presence of H3K4me3 within the CEMIP promoter. These results provide insight into the upregulation of CEMIP within cancer and can lead to novel treatment strategies targeting this cancer cell migration-promoting gene." @default.
- W2105393937 created "2016-06-24" @default.
- W2105393937 creator A5007128413 @default.
- W2105393937 creator A5008286963 @default.
- W2105393937 creator A5011733054 @default.
- W2105393937 creator A5020355643 @default.
- W2105393937 creator A5020551894 @default.
- W2105393937 creator A5030012912 @default.
- W2105393937 creator A5031542639 @default.
- W2105393937 creator A5043344689 @default.
- W2105393937 creator A5043802172 @default.
- W2105393937 creator A5064660101 @default.
- W2105393937 creator A5069387314 @default.
- W2105393937 creator A5074377710 @default.
- W2105393937 creator A5083455722 @default.
- W2105393937 creator A5086099448 @default.
- W2105393937 creator A5088057801 @default.
- W2105393937 date "2015-05-13" @default.
- W2105393937 modified "2023-10-14" @default.
- W2105393937 title "Hypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein (CEMIP)" @default.
- W2105393937 cites W1493048246 @default.
- W2105393937 cites W1555420371 @default.
- W2105393937 cites W1624342207 @default.
- W2105393937 cites W1937401270 @default.
- W2105393937 cites W1982409009 @default.
- W2105393937 cites W1984181658 @default.
- W2105393937 cites W1985180051 @default.
- W2105393937 cites W1989262480 @default.
- W2105393937 cites W1993323132 @default.
- W2105393937 cites W1997059241 @default.
- W2105393937 cites W1997499760 @default.
- W2105393937 cites W1998122056 @default.
- W2105393937 cites W2011076742 @default.
- W2105393937 cites W2012873388 @default.
- W2105393937 cites W2013041233 @default.
- W2105393937 cites W2018367009 @default.
- W2105393937 cites W2021884121 @default.
- W2105393937 cites W2024243863 @default.
- W2105393937 cites W2026411584 @default.
- W2105393937 cites W2027092476 @default.
- W2105393937 cites W2041941139 @default.
- W2105393937 cites W2048108896 @default.
- W2105393937 cites W2059255388 @default.
- W2105393937 cites W2069721794 @default.
- W2105393937 cites W2071354670 @default.
- W2105393937 cites W2074824347 @default.
- W2105393937 cites W2075500360 @default.
- W2105393937 cites W2079121632 @default.
- W2105393937 cites W2080337585 @default.
- W2105393937 cites W2085609942 @default.
- W2105393937 cites W2097607584 @default.
- W2105393937 cites W2098972920 @default.
- W2105393937 cites W2100438537 @default.
- W2105393937 cites W2102476325 @default.
- W2105393937 cites W2107619898 @default.
- W2105393937 cites W2116859091 @default.
- W2105393937 cites W2120657231 @default.
- W2105393937 cites W2130549804 @default.
- W2105393937 cites W2135056923 @default.
- W2105393937 cites W2136242764 @default.
- W2105393937 cites W2139008292 @default.
- W2105393937 cites W2144522854 @default.
- W2105393937 cites W2149538815 @default.
- W2105393937 cites W2151029652 @default.
- W2105393937 cites W2159831588 @default.
- W2105393937 cites W2161071327 @default.
- W2105393937 cites W2169405905 @default.
- W2105393937 cites W2170212327 @default.
- W2105393937 doi "https://doi.org/10.18632/oncotarget.3978" @default.
- W2105393937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4653038" @default.
- W2105393937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26009875" @default.
- W2105393937 hasPublicationYear "2015" @default.
- W2105393937 type Work @default.
- W2105393937 sameAs 2105393937 @default.
- W2105393937 citedByCount "53" @default.
- W2105393937 countsByYear W21053939372016 @default.
- W2105393937 countsByYear W21053939372017 @default.
- W2105393937 countsByYear W21053939372018 @default.
- W2105393937 countsByYear W21053939372019 @default.
- W2105393937 countsByYear W21053939372020 @default.
- W2105393937 countsByYear W21053939372021 @default.
- W2105393937 countsByYear W21053939372022 @default.
- W2105393937 countsByYear W21053939372023 @default.
- W2105393937 crossrefType "journal-article" @default.
- W2105393937 hasAuthorship W2105393937A5007128413 @default.
- W2105393937 hasAuthorship W2105393937A5008286963 @default.
- W2105393937 hasAuthorship W2105393937A5011733054 @default.
- W2105393937 hasAuthorship W2105393937A5020355643 @default.
- W2105393937 hasAuthorship W2105393937A5020551894 @default.
- W2105393937 hasAuthorship W2105393937A5030012912 @default.
- W2105393937 hasAuthorship W2105393937A5031542639 @default.
- W2105393937 hasAuthorship W2105393937A5043344689 @default.
- W2105393937 hasAuthorship W2105393937A5043802172 @default.
- W2105393937 hasAuthorship W2105393937A5064660101 @default.
- W2105393937 hasAuthorship W2105393937A5069387314 @default.
- W2105393937 hasAuthorship W2105393937A5074377710 @default.
- W2105393937 hasAuthorship W2105393937A5083455722 @default.
- W2105393937 hasAuthorship W2105393937A5086099448 @default.