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- W2105402991 abstract "Purpose Autologous stem-cell transplantation has been shown to be a curative procedure for a variety of leukemias and lymphomas. Most transplants require RBC and platelet support. We report the ability to perform autologous transplantation without blood-product support. Subjects and Methods In this study, we treated 26 patients with religious objection to blood products with autologous stem-cell support without the use of any blood products. Patients received a combination of granulocyte colony-stimulating factor (G-CSF), erythropoietin, and interleukin-11 or G-CSF alone to mobilize stem cells. Post-transplant patients received intravenous iron, erythropoietin, G-CSF, and epsilon aminocaproic acid. Results There were two major bleeding complications (8%), with two treatment-related deaths (8%). There were three minor bleeding complications (12%). The median fall in hemoglobin level was 4.7 g/dL; the median hemoglobin level 30 days after transplantation was 9.2 g/dL. The median total number of days with platelet count less than 10 × 10 9 /L was 4 days; the median days to platelet recovery greater than 20 × 10 9 /L was 12 days. Conclusion Autologous stem-cell transplantation can be performed safely without the use of any blood products." @default.
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- W2105402991 date "2004-10-15" @default.
- W2105402991 modified "2023-10-16" @default.
- W2105402991 title "Autologous Stem-Cell Transplantation Can Be Performed Safely Without the Use of Blood-Product Support" @default.
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- W2105402991 doi "https://doi.org/10.1200/jco.2004.01.144" @default.
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