Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105403162> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2105403162 endingPage "183" @default.
- W2105403162 startingPage "183" @default.
- W2105403162 abstract "Clinical utility of ivabradine in cardiovascular disease management: current status Giuseppe MC Rosano,1,2 Cristiana Vitale,1,2 Ilaria Spoletini,1 Maurizio Volterrani11Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy; 2Cardiovascular and Cell Sciences Research Institute, St George's University of London, London, UK Abstract: Ivabradine is a selective antagonist of the funny channels with anti-anginal and anti-ischemic properties, approved for the treatment of coronary artery disease (CAD) and heart failure (HF). It provides pure heart rate reduction, reducing the diastolic depolarization slope, without altering hemodynamic parameters. This review summarizes the current knowledge on the efficacy of ivabradine in patients with cardiovascular diseases, with a particular focus on its role in the clinical management of patients with CAD and HF. There is consistent evidence that ivabradine is effective in reducing angina pectoris symptoms and myocardial ischemia. At approved doses ivabradine is safe, improves exercise tolerance, and reduces heart rate. Available data from clinical trials support its use in the management of patients with stable CAD and chronic HF. Recent studies have cast doubt on the safety of non-approved high doses of ivabradine for the treatment of patients with CAD and without clinical HF, but have shown no concerns on the doses approved for clinical use. Keywords: ivabradine, coronary artery disease, heart failure, angina pectoris, exercise performance" @default.
- W2105403162 created "2016-06-24" @default.
- W2105403162 creator A5029447917 @default.
- W2105403162 creator A5048367372 @default.
- W2105403162 creator A5068884647 @default.
- W2105403162 creator A5087977641 @default.
- W2105403162 date "2014-08-01" @default.
- W2105403162 modified "2023-09-25" @default.
- W2105403162 title "Clinical utility of ivabradine in cardiovascular disease management: current status" @default.
- W2105403162 cites W1736343608 @default.
- W2105403162 cites W1985126439 @default.
- W2105403162 cites W1985431801 @default.
- W2105403162 cites W1989036742 @default.
- W2105403162 cites W1992672987 @default.
- W2105403162 cites W2001966526 @default.
- W2105403162 cites W2010864056 @default.
- W2105403162 cites W2012221083 @default.
- W2105403162 cites W2027480943 @default.
- W2105403162 cites W2045247934 @default.
- W2105403162 cites W2062837386 @default.
- W2105403162 cites W2063484906 @default.
- W2105403162 cites W2071987892 @default.
- W2105403162 cites W2079604044 @default.
- W2105403162 cites W2080011884 @default.
- W2105403162 cites W2097992015 @default.
- W2105403162 cites W2098402615 @default.
- W2105403162 cites W2100328282 @default.
- W2105403162 cites W2106313387 @default.
- W2105403162 cites W2115107692 @default.
- W2105403162 cites W2118392285 @default.
- W2105403162 cites W2119493017 @default.
- W2105403162 cites W2125532715 @default.
- W2105403162 cites W2136642260 @default.
- W2105403162 cites W2144207672 @default.
- W2105403162 cites W2151253049 @default.
- W2105403162 cites W2156416366 @default.
- W2105403162 cites W2156590637 @default.
- W2105403162 cites W2163823318 @default.
- W2105403162 cites W2170675714 @default.
- W2105403162 cites W2234326338 @default.
- W2105403162 cites W2329649037 @default.
- W2105403162 doi "https://doi.org/10.2147/rrcc.s46468" @default.
- W2105403162 hasPublicationYear "2014" @default.
- W2105403162 type Work @default.
- W2105403162 sameAs 2105403162 @default.
- W2105403162 citedByCount "0" @default.
- W2105403162 crossrefType "journal-article" @default.
- W2105403162 hasAuthorship W2105403162A5029447917 @default.
- W2105403162 hasAuthorship W2105403162A5048367372 @default.
- W2105403162 hasAuthorship W2105403162A5068884647 @default.
- W2105403162 hasAuthorship W2105403162A5087977641 @default.
- W2105403162 hasBestOaLocation W21054031621 @default.
- W2105403162 hasConcept C126322002 @default.
- W2105403162 hasConcept C164705383 @default.
- W2105403162 hasConcept C2777953023 @default.
- W2105403162 hasConcept C2777987666 @default.
- W2105403162 hasConcept C2778198053 @default.
- W2105403162 hasConcept C2778213512 @default.
- W2105403162 hasConcept C2778425758 @default.
- W2105403162 hasConcept C2779167562 @default.
- W2105403162 hasConcept C3019004856 @default.
- W2105403162 hasConcept C500558357 @default.
- W2105403162 hasConcept C71924100 @default.
- W2105403162 hasConcept C84393581 @default.
- W2105403162 hasConceptScore W2105403162C126322002 @default.
- W2105403162 hasConceptScore W2105403162C164705383 @default.
- W2105403162 hasConceptScore W2105403162C2777953023 @default.
- W2105403162 hasConceptScore W2105403162C2777987666 @default.
- W2105403162 hasConceptScore W2105403162C2778198053 @default.
- W2105403162 hasConceptScore W2105403162C2778213512 @default.
- W2105403162 hasConceptScore W2105403162C2778425758 @default.
- W2105403162 hasConceptScore W2105403162C2779167562 @default.
- W2105403162 hasConceptScore W2105403162C3019004856 @default.
- W2105403162 hasConceptScore W2105403162C500558357 @default.
- W2105403162 hasConceptScore W2105403162C71924100 @default.
- W2105403162 hasConceptScore W2105403162C84393581 @default.
- W2105403162 hasLocation W21054031621 @default.
- W2105403162 hasOpenAccess W2105403162 @default.
- W2105403162 hasPrimaryLocation W21054031621 @default.
- W2105403162 hasRelatedWork W2023157277 @default.
- W2105403162 hasRelatedWork W2131996841 @default.
- W2105403162 hasRelatedWork W2270377498 @default.
- W2105403162 hasRelatedWork W2610787159 @default.
- W2105403162 hasRelatedWork W2707576095 @default.
- W2105403162 hasRelatedWork W2795216625 @default.
- W2105403162 hasRelatedWork W2971941309 @default.
- W2105403162 hasRelatedWork W3107858219 @default.
- W2105403162 hasRelatedWork W3145040827 @default.
- W2105403162 hasRelatedWork W4318921094 @default.
- W2105403162 isParatext "false" @default.
- W2105403162 isRetracted "false" @default.
- W2105403162 magId "2105403162" @default.
- W2105403162 workType "article" @default.