Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105403719> ?p ?o ?g. }
- W2105403719 endingPage "127" @default.
- W2105403719 startingPage "117" @default.
- W2105403719 abstract "David Kupfer had a passion for drug metabolism and used his talents to understand the putative metabolic activation of the insecticides o, p'DDT and methoxychlor to estrogens. His research helped to create a scientific foundation for the current interest in endocrine disruption. With the increasing clinical significance of tamoxifen in the late 1980s, and the proposal to test tamoxifen as a breast cancer chemopreventive in healthy women, David initiated laboratory studies on the mechanisms of tamoxifen metabolism. He was the first to note that tamoxifen is metabolically activated to alkylating species. Tamoxifen and insecticides covalently bind to microsomal proteins. His contribution presaged worldwide studies of the induction of rat liver carcinogenesis by tamoxifen." @default.
- W2105403719 created "2016-06-24" @default.
- W2105403719 creator A5005756055 @default.
- W2105403719 date "2006-01-01" @default.
- W2105403719 modified "2023-09-28" @default.
- W2105403719 title "Activated Estrogens and Antiestrogens: A 30-Year Journey with David Kupfer" @default.
- W2105403719 cites W1500505511 @default.
- W2105403719 cites W1506399025 @default.
- W2105403719 cites W1559518404 @default.
- W2105403719 cites W1597612118 @default.
- W2105403719 cites W1965965888 @default.
- W2105403719 cites W1971947104 @default.
- W2105403719 cites W1977793017 @default.
- W2105403719 cites W1983360066 @default.
- W2105403719 cites W1989167667 @default.
- W2105403719 cites W1993193232 @default.
- W2105403719 cites W1995005746 @default.
- W2105403719 cites W2001664183 @default.
- W2105403719 cites W2003551554 @default.
- W2105403719 cites W2010440101 @default.
- W2105403719 cites W2019865076 @default.
- W2105403719 cites W2026683867 @default.
- W2105403719 cites W2030462656 @default.
- W2105403719 cites W2040017263 @default.
- W2105403719 cites W2042162210 @default.
- W2105403719 cites W2047177696 @default.
- W2105403719 cites W2053917307 @default.
- W2105403719 cites W2055936599 @default.
- W2105403719 cites W2062798076 @default.
- W2105403719 cites W2067806189 @default.
- W2105403719 cites W2070924990 @default.
- W2105403719 cites W2074335085 @default.
- W2105403719 cites W2075951540 @default.
- W2105403719 cites W2085867782 @default.
- W2105403719 cites W2094674411 @default.
- W2105403719 cites W2095161900 @default.
- W2105403719 cites W2097215370 @default.
- W2105403719 cites W2101738855 @default.
- W2105403719 cites W2111650618 @default.
- W2105403719 cites W2115137592 @default.
- W2105403719 cites W2116087991 @default.
- W2105403719 cites W2133293679 @default.
- W2105403719 cites W2136695719 @default.
- W2105403719 cites W2141349182 @default.
- W2105403719 cites W2145493691 @default.
- W2105403719 cites W2167674432 @default.
- W2105403719 cites W2901368272 @default.
- W2105403719 cites W4245552770 @default.
- W2105403719 doi "https://doi.org/10.1080/03602530600569893" @default.
- W2105403719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16684651" @default.
- W2105403719 hasPublicationYear "2006" @default.
- W2105403719 type Work @default.
- W2105403719 sameAs 2105403719 @default.
- W2105403719 citedByCount "2" @default.
- W2105403719 crossrefType "journal-article" @default.
- W2105403719 hasAuthorship W2105403719A5005756055 @default.
- W2105403719 hasConcept C121608353 @default.
- W2105403719 hasConcept C126322002 @default.
- W2105403719 hasConcept C134018914 @default.
- W2105403719 hasConcept C2776067312 @default.
- W2105403719 hasConcept C2777164284 @default.
- W2105403719 hasConcept C2777176818 @default.
- W2105403719 hasConcept C46699223 @default.
- W2105403719 hasConcept C502942594 @default.
- W2105403719 hasConcept C530470458 @default.
- W2105403719 hasConcept C555283112 @default.
- W2105403719 hasConcept C62231903 @default.
- W2105403719 hasConcept C71315377 @default.
- W2105403719 hasConcept C71924100 @default.
- W2105403719 hasConcept C84606932 @default.
- W2105403719 hasConcept C86803240 @default.
- W2105403719 hasConcept C89311334 @default.
- W2105403719 hasConcept C98274493 @default.
- W2105403719 hasConceptScore W2105403719C121608353 @default.
- W2105403719 hasConceptScore W2105403719C126322002 @default.
- W2105403719 hasConceptScore W2105403719C134018914 @default.
- W2105403719 hasConceptScore W2105403719C2776067312 @default.
- W2105403719 hasConceptScore W2105403719C2777164284 @default.
- W2105403719 hasConceptScore W2105403719C2777176818 @default.
- W2105403719 hasConceptScore W2105403719C46699223 @default.
- W2105403719 hasConceptScore W2105403719C502942594 @default.
- W2105403719 hasConceptScore W2105403719C530470458 @default.
- W2105403719 hasConceptScore W2105403719C555283112 @default.
- W2105403719 hasConceptScore W2105403719C62231903 @default.
- W2105403719 hasConceptScore W2105403719C71315377 @default.
- W2105403719 hasConceptScore W2105403719C71924100 @default.
- W2105403719 hasConceptScore W2105403719C84606932 @default.
- W2105403719 hasConceptScore W2105403719C86803240 @default.
- W2105403719 hasConceptScore W2105403719C89311334 @default.
- W2105403719 hasConceptScore W2105403719C98274493 @default.
- W2105403719 hasIssue "1-2" @default.
- W2105403719 hasLocation W21054037191 @default.
- W2105403719 hasLocation W21054037192 @default.
- W2105403719 hasOpenAccess W2105403719 @default.
- W2105403719 hasPrimaryLocation W21054037191 @default.
- W2105403719 hasRelatedWork W159153186 @default.
- W2105403719 hasRelatedWork W2013370943 @default.
- W2105403719 hasRelatedWork W2025170339 @default.